Institut Pasteur

Centre National De La Recherche Scientifique

Centre Nationale De La Recherche Scientifique

Shirley Longacre

Faridabano Nato

Ronald Perraut

Hannah Polson

Farida Nato

Thierry Fontaine

Charles W Roth

Sarah Bonnet

Accordingly, the invention provides constructs in which the nucleic acids encodingMSP4 and MSP5, and the resulting polypeptides, have been modified. More particularly, this invention provides constructs encoding recombinant MSP4 and MSP5 polypeptides, which are expressed as soluble, secreted polypeptides in a baculovirus-insect cell expression system. It was surprisingly found that the recombinant polypeptides contain an EGF-like domain at the C-terminus that is properly folded in the polypeptide.

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The present invention relates to a purified polypeptide comprising or consisting of a C-terminus Merozoite Surface Protein 1 (MSP1) antigen fromcarrying a Glycosyl-phosphatidyl-inositol group (GPI), an immunogenic composition and a vaccine against ainfection comprising said purified polypeptide.

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Paris, France

Shirley Longacre