Shanghai Lumosa Therapeutics Co., Ltd.

Guangzhou Baiyunshan Pharmaceutical Co., Ltd.

Shiqi Peng

Ming Zhao

Chao Wang

Jianhui Wu

Yangfen Wu

Xueyun Jiang

Yuji Wang

Qiqi Feng

The present invention discloses a novel compound with effects of thrombolysis, free radical scavenging and thrombus-targeting, as well as a preparation method and use thereof. The compound is a ternary conjugate formed by conjugating a thrombolytic peptide, a free radical scavenger and a thrombus-targeting/antithrombotic peptide together via a linking arm. The present invention also discloses a pharmaceutical composition containing the compounds, wherein the compounds form a nanospherical structure.

Compound with effects of thrombolysis, free radical scavenging and thrombus-targeting

The present invention relates to the protected intermediates and the deprotected products of P6A, related to the protected pseudopeptides introducing the protected intermediateds of P6A to 3S-(2-Boc)-1,2,3,4-tetrahydro-&#x3b2;-carboline-3-carboxylic acid and the deprotected pseudopeptides, related to the protected pseudopeptides introducing the protected intermediateds of P6A to 3S-1,2,3,4-tetrahydro-&#x3b2;-carboline-3-carboxylic acid benzyl ester, related to the methods for their preparation, and related to their use as the thrombolytic agents.

Carboline-3-carboxylic acid modified related sequences of Ala-Arg-Pro-Ala-Lys, their synthesis and use as thromobolytic agent

Growing community of inventors

Beijing, China

Shiqi Peng