Food Industry Research and Development Institute

Shiow-Wen Chen

Chi-Hua Chen

Yen-Lin Chen

Gwo-Fang Yuan

Shie-Jea Lin

Hui-Ping Chen

Kai-Ping Chen

Ming-Der Wu

Ming-Jen Cheng

Ping-Shin Yang

Yuarn-Yee Chang

Wen-Kia Liu

The present invention relates to novel pyridine alkaloid compounds of formula (I): or a pharmaceutically acceptable derivative thereof as described in the specification, the process for the preparation of the same, and the composition comprising the same. The uses of a pyridine compound for increasing the activity of PPAR&#x3b3;, for the prevention and/or treatment of a disease or disorder related to insulin resistance, and for the prevention and/or treatment of metabolic syndrome or its complication are also provided. The invention also provides extracts of red yeast-fermented products and their uses for prevention and/or treatment of a disease or disorder related to insulin resistance, such as metabolic syndrome.

Pyridine alkaloids, preparation process thereof, and the uses of the pyridine alkaloids

An extract ofThunb. ex Murray var.(Ohwi) or of(Ohwi) for improving metabolic syndrome is prepared by the following method: (a) providing fresh or dryThunb. ex Murray var.(Ohwi) or(Ohwi) in partial or whole plant; (b) extracting the partial or whole plant by a solvent to obtain a crude extract; (c) condensing and drying the crude extract to obtain an extract product; and (d) collecting the extract product. The present invention also relates to a pharmaceutical and a food composition having the above extract for improving the metabolic syndromes. The extract of the present invention can be easily prepared and is demonstrated to modulate the levels of both blood glucose and blood lipid, to inhibit the activities of glycolytic enzymes and acetyl-CoA carboxylase, and to stimulate acyl-CoA oxidase. The extract of the present invention is capable of improving metabolic syndromes.

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Growing community of inventors

Hsinchu, Taiwan

Shiow-Wen Chen