Institute of Nuclear Energy Research, Atomic Energy Council, Executive Yuan

Institute of Nuclear Energy Research, Atomic Energy Council, Executive Yuan, R.o.c

Tsinghua University

Shiou-Shiow Farn

Wuu-Jyh Lin

Jenn-Tzong Chen

Chyng-Yann Shiue

Li-Yuan Huang

Yean-Hung Tu

Cheng-Fang Hsu

Show-Wen Liu

Tsai-Yueh Luo

Ting-Shien Duh

Shu-Hung Lin

Kuan-Yin Chen

Mao-Hsung Chang

Ho-Lien Huang

Wen-Chin Su

Chung-Shan Yu

Ching-Shiuann Yang

Dow-Che Chen

Kuo-Yuan Chu

Chun-Nan Yeh

Wei-Yuan Lee

Kang-Wei Chang

Ying-Cheng Huang

Kun-Ju Lin

Shu-Fan Tien

Sheng-Po Huang

Hung-Wen Yu

Yun-Sheng Lin

Tsung-Yu Shih

Structural design of cranial nerve degeneration contrast agent precursor, the cranial nerve degeneration contrast agent prepared using the cranial nerve degeneration contrast agent precursor can be used for positron radiation tomography to detect alpha-synuclein. Since the cranial nerve degeneration contrast agent has better affinity and specificity for α-synuclein, it is helpful for more efficient early diagnosis of Parkinson's disease.

Structural design of a cranial nerve degeneration contrast agent precursors

A method is provided to purify [F-18]FEONM under a high pressure. The synthesis processes of [F-18]FEONM are integrated. An isolation process of non-toxic radio-high performance liquid chromatography (radio-HPLC) is used to purify the crude product. The method integrates a convention [F-18]FDG synthesizer and a novel radio-HPLC system together in a heat chamber. After radiofluorinating the precursor, the reaction product is purified with an alumina solid-phase column in advance to obtain the crude product while fluorine-18 is removed. Then, diphenyl semipreparative HPLC column is used for a final purification. A non-toxic solvent is used for mobile-phase eluting to remove the unreacted precursor and the phase-transfer solvent. The radiofluorination has a reaction yield about 50 percent (%). The method has an uncorrected radiochemical yield of 10&#x2dc;20%. Both of the radio-HPLC and the radio-thin layer chromatography (radio-TLC) have radiochemical purity higher than 95%.

Method of high-pressure purification of [f-18]FEONM

A [F-18]FEONM precursor is synthesized. 2-bromoethanol is added to further connect an atom of oxygen at an N terminal of the precursor. Four atoms of carbon can be further connected. Thus, better fat-solubility is obtained along with the increase in carbon. Positioning in brain imaging becomes better.

Method of fabricating [F-18]FEONM precursor

A radiocontrast agent for tau protein is provided. The agent is selectively and strongly bound to tau protein and its tangle found in brain diseases like Alzheimer's disease (AD). The agent is especially suitable to be used in PET imaging for brain diseases. Or, the agent can be used to inhibit tau protein overexpressive and, thus, stop the proceeding of brain disease.

Compound of radiocontrast agent for tau protein

The present invention provides a method of preparing [I]Iodooctyl fenbufen amide with a radiochemical yield of 15%, a specific activity of 37 GBq/&#x3bc;mol and radiochemical purity of 95%. The present invention further provides a method of applying [I]Iodooctyl fenbufen amide as tracer of single photon emission computer tomography (SPECT) to estimate the distribution of cyclooxygenase. By the binding characteristics of the iodine isotope-labeled compounds and the positive correlation of inflammation to tumor lesion, the present invention can estimate the tumor development and metastasis.

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Taoyuan, Taiwan

Shiou-Shiow Farn