Council of Scientific and Industrial Research

Nicholas Piramal India Limited

Shio Kumar Singh

Anil Kumar Dwivedi

Satyawan Singh

Arvind Kumar Srivastava

Ram Pratap

Sunil Kumar Puri

Sudhir Srivastava

Omkar Prasad Asthana

Ram Chandra Gupta

Jagdishwar Sahai Srivastava

Vikash Chandra Pandey

Pratima Srivastava

Amiya Prasad Bhaduri

Swati Ajay Piramal

Ram Raghubir

Harsh Pati Thapliyal

Guru Prasad Dutta

Chandishwar Nath

Francis Joseph Pinto

Alok Kumar Verma

Mukesh Srivastava

Amar Bahadur Singh

Himanshu Singh

A combination kit for the treatment of malaria caused by() having individual doses of an anti-malarial agent, 3-[1-[[4-[(6-methoxy-8-quinolinyl)amino]pentyl]amino]ethylidene]-dihydro-2(3H)-furanone (I) in the form of capsules; individual doses of the anti-malarial agent, chloroquine in the form of tablets; and instruction material for the administration of the two anti-malarial drugs. The combination kit is particularly suited for a 6 days treatment regimen where the treatment is rendered by five tablets containing 500 mg of chloroquine phosphate (equivalent to 300 mg base), three to be taken on day one and one each on days two and three; and five capsules containing 25 mg of 3-[1-[[4-[(6-methoxy-8-quinolinyl)amino]pentyl]amino]ethylidene]-dihydro-2(3H)-furanone (I), one each to be taken on days two to six.

Combination kit used in the treatment of malaria

The present invention a novel use of primaquine derivative N-(3-ethylidinotetrahydrofuran-2-one)-N-(6-methoxy-8-quinolinyl)-1,4-pentanediamine in the treatment and controlling the spread of malaria. In particular, the present invention discloses a method of treatment of malaria by the use of primaquine derivative N-(3-ethylidinotetrahydrofuran-2-one)-N-(6-methoxy-8-quinolinyl)-1,4-pentanediamine as a gametocytocidal agent.

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Shio Kumar Singh