Shionogi Company Limited

Shinzo Matsuura

Tadashi Yoshida

Mikao Mayama

Masayuki Narisada

Naoki Tsuji

Yoshimi Kawamura

Koichi Matsumoto

Eiji Kondo

Kouichi Matsumoto

Jun'ichi Shoji

Yoshiharu Wakisaka

Tetso Okada

Kei Okabe

The compounds of the formula: ##STR1## wherein R is ##STR2## or H, wherein X is NH.sub.2 and Y is CH.sub.3 ; or X is OH and Y is H, and their pharmaceutically acceptable salts. The compounds have a potent activity against gram-positive bacteria, especially, methicillin-resistant bacteria.

Novel glycopeptide antibiotics

7.beta.-(2-Cyano-aliphatic acylamino)-7.alpha.-methoxy-3-heterocyclic thiomethyl-1-dethia-1-oxa-3-cephem-4-carboxylic acids and salts or pharmacologically acceptable esters generically represented by the following formula are potent antibacterials and esters are prospective oral drugs: ##STR1## (wherein A is a lower alkyl, lower alkenyl or lower alkynyl group;

Cephalosporin analogs for oral use

Antibiotic siomycin A derivatives produced by reaction of siomycin A with a dicarboxylic acid. The compounds have excellent characteristics, particularly in their solubility in comparison with that of siomycin A, and are useful as medicaments.

Antibiotic siomycin A derivatives and production thereof

A new antibiotic, 342-14-I, bein useful as a medicament and veterinary drug for inhibiting the growth of gram-positive pathogenic microorganism, and a process for preparing the same, being characterized by cultivating a 342-14-I-producing strain of microorganism belonging to the Genus Bacillus in an aqueous nutrient medium under aerobic conditions.

Antibiotic 342-14-I and production thereof

Growing community of inventors

Hyogo, Japan

Shinzo Matsuura