Nec Tokin Corporation

Other

Konica Corporation

Astellas Pharma Gmbh

Teamlab Inc.

Shinya Yoshida

Toshihiko Nishiyama

Tomoki Nobuta

Gaku Harada

Masato Kurosaki

Masaya Mitani

Hiroyuki Kamisuki

Yuuji Nakagawa

Kenji Fujita

Masahiro Sase

Akinari Takada

Kenichi Nemoto

Masahiro Tanoguchi

Morito Uemura

Hiroshi Ikeda

Shuichi Nakagawa

Takashi Kikuchi

Masahiko Yamasaki

Kiichi Sato

Takahiro Akiba

Shunichi Makuta

Takao Uejima

Hirohito Saito

Toshitaka Yoshino

Illumination ornament

Provided are a method for producing a sulfonyl amidine compound, which has an excellent gonadotropin releasing hormone receptor antagonism and is useful as a therapeutic agent for gonadotropin-dependent diseases (for example, prostate cancer, breast cancer, endometriosis, uterine fibroid, prostatic hyperplasia, or the like) or a salt thereof, and a synthesis intermediate useful in the production method. The production method of the present invention controls formation of a by-product which is hardly removed unless column purification is conducted and racemization of a target compound, thereby obtaining the target compound with a high purity, and therefore, the production method is suitable for industrial production.

Method for producing sulfonyl amidine compound

The present invention provides a secondary battery and a capacitor which may provide an excellent high rate and cycle characteristic as well as sufficient electromotive force and capacity. The secondary battery and a capacitor have an active material of an electrode comprising a trimer compound comprising three units of indole or indole derivatives in condensed ring form, wherein the second position and the third position of each unit form a six-membered ring, and a proton which can be utilized as a charge carrier of the trimer compound.

Secondary battery and capacitor utilizing indole compounds

A secondary battery of a proton conductive polymer, wherein a positive electrodeand a negative electrodeare arranged facing to each other via a separator in an electrolytic solution and only a proton in a &#x3c0; conjugated polymer or a proton of a hydroxyl group in a hydroxyl-containing macromolecular as an active material of an electrode in the positive and negative electrodes participates in a charge/discharge; the secondary battery uses a membrane, which has acid resistance, oxidation resistance and a functional group having cation exchange function, as the separator

Secondary battery of proton conductive polymer

A secondary battery of a proton conductive polymer, wherein a positive electrode and a negative electrode are arranged facing to each other via a separator in an electrolyte and only a proton or a proton of a hydroxyl group in an indole trimer and a &pgr; conjugated polymer, i.e., an active material of electrode in the positive electrode and in the negative electrode participates in a charge/discharge, and a proton concentration is 5 to 40% and an anion concentration is 30 to 60% in the solution, respectively, and the anion concentration is at least higher than the proton concentration.

Secondary battery utilizing indole compounds

A time information repeating installation in a radio clock system, which receives advance notice information, distinguishes advance notice content by detecting means sets a transmission start time by addition setting means in accordance with the content, sets an additional period by change period setting means and stores the content into transmission start time storage means When the stored time agrees with the time of a main counter transmission starts. Therefore, even when a sudden time change occurs, the repeating installation can perform transmission at the reception timing of a subsidiary device. The subsidiary device can effectively update time data for summer or daylight savings time.

Time information repeating installation and time information control system

A time signal repeater, capable of selectively relaying standard time radio signals having different modulation frequencies and correcting the time based on the plurality of standard time radio signals without changing a radio correction clock side, including an antenna portion capable of receiving a standard time radio signal by a set resonance frequency, an oscillating circuit outputting a signal having a frequency of the received standard time radio signal in synchronization with the standard time radio signal received by the antenna portion, at least one frequency conversion circuit converting the frequency of the output signal of the oscillating circuit, a receiving circuit receiving as input the standard time radio signal received by the antenna portion and correcting a time of an internal clock according to a time code included in the received radio signal, a transmission circuit generating a time radio signal including a time code based on the internal clock based on the output signal of the oscillating circuit or the signal converted in frequency by the frequency conversion circuit at the time of transmission, and a selecting circuit receiving as input the output signal of the oscillating circuit or the signal converted in frequency by the frequency conversion circuit to the transmission system circuit, and a time correction system using the same.

Time signal repeater and time correction system using the same

A time signal repeater enabling a radio correction clock to receive a relayed radio signal without regard as to the position of arrangement and without complicated trouble, including a reception circuit for receiving a standard time radio signal and correcting an internal clock to a time according to the time code included in the received radio signal and a transmission circuit for generating and transmitting time radio signals which have different intensities and include time codes based on the internal clock at a plurality of predetermined times, and a time correction system using the same.

Disclosed are a peroxidase composition and an antibody composition with high stability. In the compositions of the present invention, a substituted benzene ring having at least one hydroxyl group and at least one substituting group selected from the group consisting of groups with a Hammett sigma value .sigma. p of not more than -0.20, groups with a Hammett sigma value .sigma. p of not less than +0.24 and amide group is contained as a stabilizer for stabilizing the activity of peroxidase or the antibody.

Stabilized peroxidase compositions and antibody compositions

A substantially purified cancer-related galactosyltransferase and a monoclonal antibody which may be used as a diagnostic reagent of cancer are disclosed. The galactosyltransferase of the present invention has a molecular weight of about 50,000 determined by SDS-polyacrylamide gel electrophoresis under reducing conditions and has a reactivity with MAb4880 under native conditions. A part of the galactosyltransferase self-associates and its reactivity with MAb4880 and the degree of self-association are promoted when it is reduced so that a part of which is detected in a fraction of a molecular weight of not less than 200,000 in gel permeation chromatography. The galactosyltransferase of the present invention can be used as a cancer marker or as a reagent for preparing a monoclonal antibody with a specificity to the galactosyltransferase, which monoclonal antibody can be used as a diagnostic of a cancer. The monoclonal antibody of the invention specifically reacts with the cancer-related galactosyltransferase of the invention.

Cancer-related human galactosyltransferase GT-II

Growing community of inventors

Tokyo, Japan

Shinya Yoshida