Takasago International Corporation

Toshiba Medical Systems Corporation

Tokai University Educational System

Tokai University Educational Systems

Other

Mitsumi Electric Company Ltd.

Shinya Yamada

Toshimitsu Hagiwara

Yoji Hori

Hitoshi Kanazawa

Yoshiki Okeda

Hironori Maeda

Yukiharu Iwaya

Takahiro Ishikawa

Tadahide Hatakeyama

Tokunori Kimura

Hitoshi Kondo

Masaaki Umeda

Akio Yamaguchi

Mamoru Yamada

Masato Murai

Amane Mochizuki

Junichi Noro

Tohru Kobayashi

Hideki Nara

Ken Suzuki

Toshikazu Ogino

Hideo Yajima

Shusaku Nakano

Yuji Nakayama

Tsutomu Hashimoto

Hisanori Itoh

Akio Tachikawa

Shunichi Harada

Yoshiki Hasegawa

Kouji Ishiguro

A method for releasing an aldehyde or ketone of formula (2) by allowing a hydrolase to act on a compound of formula (1) is disclosed. The compound of formula (1) is used as a flavor or fragrance precursor. In formulas (1) and (2), each of R, Rand Rindependently represents a hydrogen atom, an alkyl group which may have a substituent, a cycloalkyl group which may have a substituent, an alkenyl group which may have a substituent, an aryl group which may have a substituent, or an aralkyl group which may have a substituent; Rand Ror Rand Rmay form a ring; Ar represents an aryl group which may have a substituent:

Method for releasing aldehyde or ketone

A fragrance precursor represented by formula (1): wherein Rrepresents a hydrogen atom, an alkyl group having a carbon number of 1 to 12, a hydroxy group, a methoxy group or an ethoxy group Rrepresents a single bond, an alkylene group having a carbon number of 1 to 2, which may have a substituent, or a vinylene group which may have a substituent; and Rrepresents a residue resulting from removal of one hydrogen atom of a hydroxy group from a fragrance alcohol having a carbon number of 5 to 20 or a phenol which may have a substituent.

Perfume precursor

The present invention relates to a method for releasing an unsaturated aldehyde or ketone represented by the general formula (2) by irradiating the compound represented by the general formula (1) with light, in which the compound represented by the general formula (1) is used as a flavor or fragrance precursor: 

Method for releasing unsaturated aldehyde or ketone

An object of the present invention is to provide a method for manufacturing an optically active menthol having fewer steps, which generates less environmentally polluting waste because a catalytic reaction is involved in all of the steps, and is capable of saving a production cost. The present invention relates to a method for manufacturing an optically active menthol, including the following steps: A-1) asymmetrically hydrogenating at least one of geranial and neral to thereby obtain an optically active citronellal, B-1) conducting a ring-closure reaction of the optically active citronellal in the presence of an acid catalyst to thereby obtain an optically active isopulegol, and C-1) hydrogenating the optically active isopulegol to thereby obtain an optically active menthol.

Method for manufacturing optically active menthol

The present invention provides a catalyst used for manufacturing an optically active carbonyl compound by selective asymmetric hydrogenation of an &#x3b1;, &#x3b2;-unsaturated carbonyl compound, which is insoluble in a reaction mixture, and a method for manufacturing the corresponding optically active carbonyl compound. Particularly, the invention provides a catalyst for obtaining an optically active citronellal useful as a flavor or fragrance, by selective asymmetric hydrogenation of citral, geranial or neral. The invention relates to a catalyst for asymmetric hydrogenation of an &#x3b1;, &#x3b2;-unsaturated carbonyl compound, which comprises: a powder of at least one metal selected from metals belonging to Group 8 to Group 10 of the Periodic Table, or a metal-supported substance in which the at least one metal is supported on a support; an optically active cyclic nitrogen-containing compound; and an acid, and also relates to a method for manufacturing an optically active carbonyl compound using the same.

Catalyst for asymmetric hydrogenation and method for manufacturing optically active carbonyl compound using the same

A velocity-image creating unit creates a velocity image that indicates a distribution of velocity components with respect to each of a plurality of images obtained by repeating a plurality of number of times Echo Planar Imaging (EPI) that is capable of obtaining velocity components of a Cerebrospinal Fluid (CSF) flowing inside a subject. A velocity-variance image creating unit calculates variance of velocity components along the time sequence by same position on velocity images by using a plurality of created velocity images. A superimposed-image processing unit then superimposes the distribution of the variance of the velocity components according to the velocity-variance image on an average absolute-value image, and an image display unit displays a superimposed image.

Determining velocity of cerebrospinal fluid by magnetic resonance imaging

The present invention provides a catalyst used for manufacturing an optically active carbonyl compound by selective asymmetric hydrogenation of an &#x3b1;,&#x3b2;-unsaturated carbonyl compound, which is insoluble in a reaction mixture, and a method for manufacturing the corresponding optically active carbonyl compound. Particularly, the invention provides a catalyst for obtaining an optically active citronellal useful as a flavor or fragrance, by selective asymmetric hydrogenation of citral, geranial or neral. The invention relates to a catalyst for asymmetric hydrogenation of an &#x3b1;,&#x3b2;-unsaturated carbonyl compound, which comprises: a powder of at least one metal selected from metals belonging to Group 8 to Group 10 of the Periodic Table, or a metal-supported substance in which the at least one metal is supported on a support; an optically active peptide compound; and an acid, and also relates to a method for manufacturing an optically active carbonyl compound using the same.

A magnetic resonance imaging apparatus includes an imaging unit which applies a labeling pulse to invert a spin included in a labeling region within part of a imaging region and then collects a echo signal from a time point when an inversion time has passed from the application of the labeling pulse, and a control unit, the control unit controlling the imaging unit so that the echo signal in the imaging region is collected a plurality of times with variations in the inversion time, the control unit also controlling the imaging unit so that a time ranging from a reference time point within a biological signal obtained from a subject to the application of the labeling pulse is a time determined in accordance with the inversion time.

Magnetic resonance imaging apparatus and magnetic resonance imaging method

This invention provides a polymerizable liquid crystal compound having a large value of &Dgr;n/n, excellent in coating properties on an alignment film and easily aligned. Disclosed is a polymerizable liquid crystal compound having at least one polymerizable reactive group and showing nematic liquid crystal properties, having a &Dgr;n/n value of 0.14 or more wherein n is average refractive index and &Dgr;n is extraordinary light refractive index (ne) minus ordinary light refractive index (no), and being aligned by application onto an alignment film.

Polymerizable liquid crystal compound and optical film

A process for producing a pivaloylacetic acid ester comprises reacting pivaloyl chloride with an acetoacetic acid ester of an alkyl group having 1 to 4 carbon atoms in the presence of at least one nitrogen-containing basic compound (a) selected from among pyridine compounds, N,N-dialkylanilines and imidazole compounds and from 0.01 to 0.5 mole equivalent, based on the pivaloyl chloride, of a magnesium compound (b) to thereby prepare a pivaloylacetoacetic acid ester and then alcholyzing or alkali-hydrolyzing the pivaloylacetoacetic acid ester to thereby give a pivaloylacetic acid ester having a high purity at a low cost.

Process for producing pivaloyl-acetic acid ester

Process for producing optically active 3,7-dimethyl-6-octenol and process for producing intermediate therefor

Cis-3,7-dimethyl-2,7-octadienylamine containing from 2 to 10% by weight cis-3,7-dimethyl-2,7-octadienylamine is prepared by subjecting a mixture of an alkylamine and isoprene in a molar ratio of 1:4 to 1:4.5 to telomerization at 80 to 100&deg; C. for from 2.5 to 3.5 hours in the presence of an alkyllithium catalyst and/or phenyllithium catalyst.

An optically active compound which itself generally exhibits no antiferroelectric liquid crystal phase, but which can be added to an antiferroelectric liquid crystal or composition thereof having a high threshold voltage to reduce the threshold voltage of the resulting composition. Also disclosed is an antiferroelectric liquid crystal composition containing the optically active compound, a process for reducing the threshold voltage of an antiferroelectric liquid crystal composition, a process for producing the optically active compound, and a process for producing an optically active carboxylic acid as an intermediate.

Growing community of inventors

Kanagawa, Japan

Shinya Yamada