Sumitomo Dainippon Pharma Co., Ltd.

Dainippon Sumitomo Pharma Co., Ltd.

Shinya Usui

Hiroki Yamaguchi

Yoko Nakai

A medicament for treating diseases associated with cholinergic properties in the central nervous system (CNS) and/or peripheral nervous system (PNS), diseases associated with smooth muscle contraction, endocrine disorders, neurodegenerative disorders and the like, which comprises a compound of Formula (I): wherein A is CRor a nitrogen atom, X&#x2014;Y&#x2014;Z is N&#x2014;CO&#x2014;NRRand the like, Rto Rare each independently a hydrogen atom and the like, Rto Rare each independently a hydrogen atom and the like, Rand Rare each independently an optionally-substituted Ccycloalkyl and the like, and n is 1 or 2or a pharmaceutically acceptable salt thereof, which exhibits potent modulatory-effects on the activity of &#x3b1;7 nicotinic acetylcholine receptor (&#x3b1;7 nAChR).

1-substituted indazole derivative

A medicament for treating diseases associated with cholinergic properties in the central nervous system (CNS) and/or peripheral nervous system (PNS), diseases associated with smooth muscle contraction, endocrine disorders, neurodegenerative disorders and the like, which comprises a compound of Formula (I), wherein A is CRor a nitrogen atom, X&#x2014;Y&#x2014;Z is N&#x2014;CO&#x2014;NRRand the like, Rto Rare each independently a hydrogen atom and the like, Rto Rare each independently a hydrogen atom and the like, Rand Rare each independently an optionally-substituted C3-10 cycloalkyl and 15 the like, and n is 1 or 2 or a pharmaceutically acceptable salt thereof, which exhibits potent modulatory-effects on the activity of alpha-7 nicotinic acetylcholine receptor (alpha-7 nAChR).

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Osaka, Japan

Shinya Usui