Otsuka Pharmaceutical Company, Limited

Shinya Ohtsuka

Hideo Tanaka

Satoshi Yamada

Takashi Suzuki

Koji Sakai

Shigekazu Fujita

Takumi Sumida

Yutaka Kojima

Yasuo Yanagihara

Keisuke Miyajima

Yosuke Sato

Hideki Takasu

Kazuo Sekiguchi

Kazuhisa Sugiyama

Mitsuhiro Okuno

Toshiyuki Hirose

The present invention provides a novel compound having an excellent antitumor effect. The compound of the present invention is represented by the following general formula (1) wherein Rand Rare aryl or the like; A is lower alkylene; Ring X is optionally substituted arylene; E is bond or lower alkenylene; Ring Y is optionally substituted heterocycloalkylene containing one or more nitrogen atoms, one of which is attached to the adjacent carbonyl group; G is &#x2014;NH-G-, &#x2014;N(lower alkyl)-G-, &#x2014;NH&#x2014;CH-G-, &#x2014;N(lower alkyl)-CH-G- or &#x2014;CH-G-, [wherein Gbinds to R, G-Ris bond-R, phenylene-G-R, phenylene-G-O&#x2014;R, phenylene-G-NH&#x2014;R, phenylene-G-N(lower alkyl)-Ror quinolinediyl-O&#x2014;R, the phenylene of said phenylene-containing groups being optionally substituted with one or more substituents; G-Ris &#x2014;O-lower alkylene-Ror the like; G-O&#x2014; is lower alkylene-O&#x2014; or the like; Gis lower alkylene; Gis lower alkylene]. 

Di-substituted pyridine derivatives as anticancers

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Osaka, Japan

Shinya Ohtsuka