Astellas Pharma Gmbh

Ando Electric Company

Shinya Nagashima

Hiroshi Nagata

Makoto Takeuchi

Hiroyuki Moritomo

Sadao Kuromitsu

Eiichi Nakai

Masaki Yokota

Keiko Ohga

Ryo Sato

Satoshi Aoki

Hiroshi Yamada

Koichi Yonezawa

Satoshi Miyamoto

Akio Kamikawa

Hisao Hamaguchi

Yuji Matsushima

Masahiro Iwata

Shigeki Kunikawa

Toru Kontani

Shimpei Kawakami

Yohei Koganemaru

Yuka Koizumi

Takashi Ogiyama

Shuichirou Kakimoto

Masashiro Iwata

Tadatsura Koshika

Keisuke Tamaki

Junichi Shishikura

[Problem] Provided is a compound having a positive allosteric modulating activity (PAM activity) on an &#x3b1;7 nicotinic acetylcholine receptor (&#x3b1;7 nACh receptor). [Means for Solution] The present inventors have studied on a PAM activity on an &#x3b1;7 nACh receptor, and they have found that a tetrahydrooxepinopyridine compound has a PAM activity on an &#x3b1;7 nACh receptor, thereby completing the present invention. The tetrahydrooxepinopyridine compound of the present invention has a PAM activity on an &#x3b1;7 nACh receptor and can be expected as an agent for preventing or treating dementia, cognitive impairment, schizophrenia, Alzheimer's disease, CIAS, negative symptoms of schizophrenia, inflammatory diseases, or pain.

Tetrahydrooxepinopyridine compound

[PROBLEMS] Provided is a compound which has an antagonistic action on a muscarinic Mreceptor and is useful as an active ingredient of a prophylactic and/or therapeutic agent for an inflammatory disease such as a chronic obstructive pulmonary disease (COPD), asthma and the like. [MEANS For SOLVING PROBLEMS] The present inventors have made studies on a compound having an antagonistic action on the binding of a muscarinic Mreceptor, and they have found that an aza-bridged-ring compound or a salt thereof has an antagonistic action on the binding of a muscarinic Mreceptor, thereby completing the present invention. The aza-bridged-ring compound of the present invention has an antagonistic action on the binding of a muscarinic Mreceptor, and can be used as a prophylactic and/or therapeutic agent for an inflammatory disease such as a chronic obstructive pulmonary disease (COPD), asthma and the like.

Aza-bridged-ring compound

A compound which may be used for the prevention or treatment of respiratory diseases in which STAT 6 is concerned, particularly asthma, chronic obstructive pulmonary disease and the like is provided. A pyrimidine derivative or a salt thereof, which has an arylamino or arylethylamino group which may be substituted with a specified substituent, at the 2-position, amino group substituted with benzyl group or the like, at the 4-position, and carbamoyl group which may be substituted, at the 5-position, is provided.

Diaminopyrimidinecarboxamide derivative

Each of beams originated from a light source to be measured and a white light source is branched by a beam splitter into two beams, which are reflected by a fixed and a movable mirrors respectively to meet each other again so as to generate interfering light, the white light being maximum in interfering efficiency when the optical path reaching the movable mirror is equal in length to that reaching the fixed mirror. The interfering light originated from the light source is converted into an electric signal by a first light receiver and further into pulses by a first converter. A length measuring machine outputs a pulse signal corresponding to the moving length of the movable mirror. A second light receiver converts the interfering light originated from the white light source into an electric signal. When it exceeds a set value, a second converter supplies an origin signal to the interfering light counting portion and the distance counting portion so that they start counting pulses and the position detecting portion outputs a position detecting signal when the movable mirror is moved for an arbitrary distance. A calculator calculates the wavelength of the light to be measured based on the counted values to display the result on a display. As a result, it is possible to provide an optical wavemeter which is increased in effective length of scale by permitting light originated from a white light source to be incident to an interferometer to find the position of the movable mirror where interfering efficiency is maximum and performing calibration as far as an arbitrary moving distance relative thereto.

Optical wavemeter employing a length measuring machine with a white

The purpose of the present invention is to provide a highly accurate optical wavelength meter in which the accurate starting and stop points of the measurement are detected. In accordance with the present invention, a detector which detects the back-shift of the moving mirror due to elastic force of the belt and an up-down counter which measures the amounts of the overshoot and the back-shift of the moving mirror so as to cancel the overshoot and the back-shift are provided, by which the accurate starting and stop points of the measurement can be detected.

Optical wavelength meter with an up-down counter which measures the

Growing community of inventors

Tokyo, Japan

Shinya Nagashima