Meiji Co., Ltd.

Shinya Nagafuchi

Makoto Yamaguchi

Yoshitaka Nakamura

Takeshi Takahashi

Yoshihiro Kanamaru

Hideo Ohtomo

Kenichi Nakazawa

Shuji Ikegami

Katsunori Kimura

Masaki Terahara

Seiko Narushima

Toshihiro Sashihara

Yoshihiro c/o Faculty Of Agriculture Kanamaru

A probioticwas discovered from lactobacilli of thegenus independently isolated from human adult feces. The probioticwas selected from other bacterial strains for: (1) being highly resistant to gastric acid/bile acid; (2) having a high promoting activity on IL-12 production from mouse derived spleen cells and a high Th1/Th2 balance-improving effect; (3) having a high ability to inhibit the production of antigen-specific IgE induced by intraperitoneally administering ovalbumin to BALB/c mice; (4) having a high ability to inhibit the production of antigen-specific IgE induced by orally administering a food antigen to C57BL/6N mice; (5) having a high Natural Killer cell-activating ability; (6) having a high IL-12 production-promoting activity on spleen cells and mesenteric lymph node cells derived from mice immunized with ovalbumin and a high Th1/Th2 balance-improving effect; and (7) having a high ability to suppress eosinophilia induced by a cedar pollen-extracted antigen. This discovery led to the completion of the present invention.

Immune function modulating agents

The present inventors discovered that microfiltration retentates of whey, and products obtained by treating whey using centrifugation and/or ammonium sulfate precipitation, have the activity of inhibiting rotavirus infection. In one embodiment, the present invention provides a method of preventing rotavirus infection, comprising administering to a subject a composition that comprises a whey cream serum obtained by treating whey by centrifugation, or a dehydrated product thereof, wherein the antiviral activity of said composition is retained after heat treatment.

Compositions against rotavirus infection and processes for producing the same

The present inventors discovered that microfiltration retentates of whey, and products obtained by treating whey using centrifugation and/or ammonium sulfate precipitation, have the activity of inhibiting rotavirus infection.

Growing community of inventors

Kanagawa, Japan

Shinya Nagafuchi