Otsuka Pharmaceutical Factory, Inc.

Shinya Miki

Yoshihiko Tsuda

Yasuhide Inoue

Kazuyoshi Miyata

Yasuhiro Sakai

Norihiro Yoshinaga

Yasuo Shoji

Masako Doi

Akifumi Hagi

Keigo Sato

Seiichirou Kanou

Takahiro Tomoyasu

Akiyoshi Kuroda

The present invention provides a phosphonic acid diester compound represented by General Formula wherein R, R, Rand Rare the same or different, and represent hydrogen, halogen, lower alkyl or lower alkoxy; Ris phenyl having on the phenyl ring 1&#x2013;3 substituents selected from the group consisting of lower alkyl, halogen-substituted lower alkyl, lower alkoxy, halogen-substituted lower alkoxy, phenoxy, benzyloxy, hydroxyl, halogen, nitro, lower alkylthio, di(lower alkyl)amino, lower alkanolyamino, pyrrolidinyl and phenyl, or the like, provided that Ris not mono(lower alkoxy)pheny; and Ris lower alkyl;and an ACAT-1 inhibitor containing the compound as an active ingredient.

Phosphonic diester derivatives

Growing community of inventors

Itano-gun, Japan

Shinya Miki