Toray Industries, Inc.

Johnson and Johnson Vision Care, Inc.

Oncolys Biopharma, Inc.

Shinya Kiguchi

Hiroya Koyama

Masataka Nakamura

Mitsuru Yokota

Katsuyuki Nagai

Takehiro Kohara

Kimihiro Kamasaka

William Ewan Hume

Satoshi Tsujimoto

Satoshi Umeda

Ewan William Hume

Disclosed is a method for mass-producing 4'-ethynyl d4T (4&#x2032;-ethynyl-2&#x2032;,3&#x2032;-didehydro-3&#x2032;-deoxythymidine) by a simpler process at low cost. Specifically disclosed is a method for producing 4&#x2032;-ethynyl d4T, which is characterized by comprising a step for introducing a triple bond-containing group into a furfuryl alcohol derivative or a levoglucosenone, by reacting the furfuryl alcohol derivative or levoglucosenone with a certain compound, and a step for reacting a compound represented by the formula (III), which is obtained by the aforementioned step, with thymine.

Method for producing 4'-ethynyl d4T

In one aspect, the invention relates to methods of synthesizing acryloyl compounds, comprising the step of hydrosilylating a compound having the structure: with a compound having the structure A-H, wherein A comprises a siloxanyl group, to yield a compound having the structure: Compounds and compositions produced thereby can effectively attain a satisfactory balance between high oxygen permeability and hydrophilicity while achieving an acceptably low concentration of undesirable impurities. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

Acryloyl materials for molded plastics

Growing community of inventors

Hyogo, Japan

Shinya Kiguchi