Tohoku University

Fuso Pharmaceutical Industries, Ltd.

Gunma University

Junsei Educational Institution

Shinya Kida

Osamu Yamada

Haruhisa Kikuchi

Yoshiteru Oshima

Jing Zhang

Toshio Hattori

Yuzuru Kubohara

Yoshihisa Matsushita

Shinya Murase

The present invention provides a compound of formula (I): or a pharmaceutically acceptable salt thereof, wherein R, R, m and n are as defined in the specification, with an inhibitory effect of PD-L1 expression and an inhibitory effect of reduced production of IL-2 and a medicament useful for the treatment of a disease associated with the reduced immune function caused by the formation of PD-1/PD-L1 binding.

Compound having PD-L1 expression-suppressing action

The present invention provides a useful medicament for the treatment and/or prophylaxis of a disease associated with the enhancement of OPN production including cancer, which comprises a compound of formula: wherein R, R, R, R, R, R, R, m, n, p, X, and Y are as defined in the specification, a pharmaceutically acceptable salt thereof.

Amide derivative

The present invention provides a medicament useful for treatment and/or prevention of cancer, a vaccine adjuvant, and an inhibitor of immune checkpoint comprising a compound of formula (I): or a pharmaceutically acceptable salt thereof, wherein Bonds a-d, Ring A, R, R, R, R, R-R, and n are as defined in the present specification.

Indole alkaloid compound having immune checkpoint inhibitory action

Disclosed herein is an osteopontin production inhibitor capable of preventing a disease resulting from increased production of osteopontin. The osteopontin production inhibitor contains a dictyopyrone derivative or a dihydrodictyopyrone derivative as an active ingredient. The dictyopyrone derivative is preferably a compound represented by Chemical Formula 1 or 2, and the dihydrodictyopyrone derivative is preferably a compound represented by Chemical Formula 3 or 4.

Osteopontin production inhibitor containing dictyopyrone derivative or dihydrodictyopyrone derivative as active ingredient

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Osaka, Japan

Shinya Kida