Shimadzu Corporation

Kyoto University

Shinya Imamura

Jun Yanagibayashi

Keisuke Ogawa

Masataka Nikko

Kenichi Yasunaga

Daisuke Kitabayashi

Tomohiro Gomi

Shinji Tanaka

Masahide Gunji

Yoshiaki Maeda

Toshiki Sano

Ryo Hosono

Shinichi Fujisaki

Yasushi Ishihama

Hiromu Yamasaki

Koshi Abe

Koshi Imami

Yumi Komori

Tomoya Niinae

An LC system includes a liquid delivery checker configured to execute a liquid delivery check mode of setting a predetermined flow rate to a liquid delivery pump and operating the liquid delivery pump at a timing different from analysis of a sample in order to check a liquid delivery flow rate of the liquid delivery pump, and a measuring instrument for measuring an amount of a mobile phase delivered by the liquid delivery pump during the liquid delivery check mode. The liquid delivery checker is configured to obtain an actual measurement value of a flow rate of a mobile phase when operating the liquid delivery pump by setting the predetermined flow rate to the liquid delivery pump using a measurement value obtained by the measuring instrument in the liquid delivery check mode.

Liquid chromatography analysis system

A pump unit includes a pump and a metal ion trap. The pump includes a metal member that comes into contact with a mobile phase. The pump pumps a mobile phase through a flow path. The metal ion trap includes a filter element. The filter element includes a metal ion retention structure for retaining metal ions by interacting with the metal ions included in a mobile phase. The filter element is provided in the flow path for a mobile phase pumped by the pump. The pump unit may be provided in a chromatograph.

Pump unit and chromatograph

A resin tube is prepared. Further, a formation tool having a pressing surface and a projection that projects from the pressing surface and is insertable into the resin tube is prepared. The projection of the formation tool is inserted from an end of the resin tube into the resin tube. The pressing surface of the formation tool is pressed against an end surface of the resin tube. Thermal energy is applied to the end of the resin tube, whereby a shape of the pressing surface of the formation tool is transferred to the end surface of the resin tube, and the end of the resin tube is formed into a flange shape.

Resin-tube end formation method and formation tool

A liquid sending failure detector acquires periodically a liquid sending pressure of a liquid sending mechanism consecutively sends liquid using at least one plunger pump that sends liquid by reciprocally driving a plunger such that a fluctuation is read in one driving period of the liquid sending mechanism, and detect a liquid sending failure of the liquid sending mechanism using an acquired liquid sending pressure. The liquid sending failure detector executes a pulsation detection step of obtaining a fluctuation range of the liquid sending pressure in a certain driving period of the liquid sending mechanism and detecting pulsation on a condition that a count of consecutive periods in which the fluctuation range exceeds a predetermined reference value exceeds a predetermined reference count, and a liquid sending failure detection step of detecting a liquid sending failure of the liquid sending mechanism when the pulsation is detected in the pulsation detection step.

Liquid sending system for liquid chromatograph

A liquid feeding device includes a primary plunger pump; a secondary plunger pump connected downstream; a check valve provided between the primary plunger pump and the secondary plunger pump; a primary pressure sensor that detects a pressure in the pump chamber of the primary plunger pump; a liquid feeding control part configured to control operations of the primary plunger pump and the secondary plunger pump; and a liquid leakage detector configured to detect liquid leakage in the check valve based on a change in an output value of the primary pressure sensor during the waiting time. The liquid feeding control part is configured to control the operation of the primary plunger pump so that a waiting time, where the primary plunger pump stops without operating, is present while a discharge operation by the secondary plunger pump is performed after a suction by the primary plunger pump is completed.

Liquid feeding device

Liquid sent by a liquid sending pump flows through an analysis flow path. A sample is injected into the analysis flow path. A separation column is provided in the analysis flow path. A sample injected in the separation column is separated into components, and sample components obtained by separation are detected by a detector. The number of liquid sending pumps and a connection structure of the liquid sending pumps connected to the analysis flow path are specified by a system configuration specifier as a system configuration. A condition for detecting a liquid sending failure in a liquid sending pump that is preset for each type of system configuration is held by a condition holder. A condition corresponding to a system configuration is determined from conditions held by the condition holder. A liquid sending failure in a liquid sending pump is detected with use of the determined condition.

Liquid chromatographic system

A backup ring is for contacting with and supporting a plunger seal which is for sealing a pump chamber provided in a pump head of a plunger type liquid feeding pump. The backup ring includes a maximum outer diameter portion of a cylindrical shape and a smaller outer diameter portion. The maximum outer diameter portion includes a maximum outer diameter in a plunger seal supporting surface side that makes contact with a rear surface of the plunger seal. The smaller outer diameter portion includes a smaller outer diameter than the maximum outer diameter portion in at least one part of a portion other than the maximum outer diameter portion.

Backup ring and liquid feeding pump using backup ring

A liquid sending device includes a plunger pump, which performs an intake operation of liquid to and a discharge operation of liquid from a pump chamber and in which pressure in the pump chamber in a case where the intake operation is performed is lower compared to a case where the discharge operation is performed, a check valve that is provided at an inlet port, has a spherical valve element and a valve seat, and passively operates according to the pressure in the pump chamber in such a direction that the valve element is seated on or detached, a pressure sensor that detects the pressure, and an attachment detector that compares the pressure with a preset threshold value and detect attachment of the valve element to the valve seat in a case where the pressure in the pump chamber is equal to or lower than the threshold value.

Liquid sending device

Even though a pump head part is finally fixed to a pump body with a fixing member, the pump head part is movable relative to the pump body perpendicular to the axial direction of a plunger at a stage before the pump head part is fixed with the fixing member. In this state, if a plunger driving part is moved to a predetermined location on the front end side of the pump body and the pump head part and the plunger driving part are fitted to each other, the pump head part is positioned where the center axis of the plunger and the center axis of the pump chamber are substantially aligned. By fixing the pump head part to the pump body with the fixing member at this location, it is possible to assemble a plunger pump with the center axis of the plunger and the center axis substantially aligned.

Plunger pump

The liquid feeding device includes a discharge speed calculation part configured to calculate a discharge speed v of the plunger pump so that a converted value Lunder an atmospheric pressure of a flow rate Lof the mobile phase discharged to the discharge channel from the pump part becomes a set flow rate Lusing a volume V of the mobile phase in the pump chamber of the closing pump immediately before the precompression process is started, a volume &#x394;V reduced due to the precompression process of the mobile phase in the pump chamber of the closing pump, and a feeding pressure P; and a discharge operation controller configured to control a discharge speed of the plunger pump to a discharge speed v calculated by the discharge speed calculation part.

Liquid feeding device and fluid chromatograph

A switching valve is used in a binary pump. The switching valve is provided with a first liquid delivery port to which a first pump unit is connected, a second liquid delivery port to which a second pump unit is connected, and an output port leading to an output unit that outputs a liquid to be delivered. The switching valve is configured so as to be switched to any one of the following states: a first state in which the first liquid delivery port is connected to the output port and the second liquid delivery port is not connected to any port; a second state in which the second liquid delivery port is connected to the output port and the first liquid delivery port is not connected to any port; and a third state in which both the first liquid delivery port and the second liquid delivery port are connected to the output port.

Switching valve, binary pump, and liquid chromatograph with binary pump

A check valve is provided with a rectilinear flow passage having a liquid inlet and a liquid outlet and allowing a liquid to flow therethrough in one direction, and a first valve body, a first valve seat, a second valve body, and a second valve seat are provided in the rectilinear flow passage. A first drive body is provided in the rectilinear flow passage at a position closer to the liquid inlet than the first valve body so as to be movable in one direction. The first drive body is driven in one direction by the drive mechanism. The drive mechanism is adapted to set the first drive body either to an open state in which the first drive body presses the first valve body toward the liquid outlet side to detach the first valve body from the first valve seat or to a closure state in which the first drive body does not press the first valve body toward the liquid outlet but allows the first valve body to be seated on the first valve seat. A second drive body is provided in the rectilinear flow passage at a position between the first valve body and the second valve body so as to be movable in one direction. When the first drive is set to the open state, the second drive body is pressed by the first valve body toward the liquid outlet to press the second valve body toward the liquid outlet, thereby detaching the second valve body from the second valve seat, and when the first drive body is set to the closure state, the second drive body is moved away from the second valve body to allow the second valve body to be seated on the second valve seat.

Check valve and liquid delivery pump

A liquid feeding apparatus has a primary side pump and a secondary side pump, and an outlet part of the primary side pump and an inlet part of the secondary side pump are connected to each other via a check valve. A temporary side pump pressure sensor for detecting the pressure inside the pump chamber of the primary side pump and a secondary side pressure sensor for detecting the pressure inside the pump chamber of the secondary side pump are provided. The signal of the primary side pressure sensor and the signal of the secondary side pressure sensor are acquired after the suction operation of the primary side pump is terminated and before the discharge operation of the secondary side pump is terminated.

Liquid delivery device

A plunger seal is mounted on the pump head, has a through hole for allowing penetration of the plunger, and holds the outer circumferential surface of the plunger and also seals an opening of the pump chamber. A backup ring is mounted on the pump head by being interposed between the plunger seal and the tip end surface of the pump body. The backup ring has a through hole, for allowing penetration of the plunger, formed in a manner not allowing the plunger seal to enter a gap to the outer circumferential surface of the plunger, and also has a liquid passage element for allowing the cleaning liquid in the cleaning space to reach the plunger seal through the through hole.

Liquid delivery pump

A recess into which a protrusion of a plunger seal is to be fitted is provided at a part of a pump head where a plunger is to be inserted into a pump chamber. The plunger seal seals the pump chamber by an outer circumferential surface of the protrusion coming into close contact with an inner circumferential surface of the recess and a surface of a flange on the side of the protrusion coming into close contact with a circumferential edge surface of the recess of the pump head due to the protrusion being fitted into the recess and being pressed by a backup ring toward the pump chamber. The inner circumferential surface of the recess of the pump head and the circumferential edge surface of the recess are covered by a film of an acid-resistant material.

Growing community of inventors

Kyoto, Japan

Shinya Imamura