Shionogi Company Limited

Shinya Hisakawa

Toshiaki Aoki

Kenji Yamawaki

Jun Sato

Yasushi Hasegawa

Yasuhiro Nishitani

Masayuki Sano

Hideki Sugimoto

Katsuki Yokoo

Hiroki Kusano

Yutaka Yokota

Masatoshi Takeo

Mikito Asai

Yusuke Takeoka

The invention relates to processes for the production of intermediates for preparing 2-alkyl cephem compounds useful as antimicrobial drugs. The invention provides a process which comprises oxidating a compound of the formula (I) or a salt thereof to give a compound of the formula (II) or a salt thereof wherein each symbol is as defined in the specification. 

Processes for production of intermediates for 2-alkyl cephem compounds

The present disclosure describes Cephem compounds of the formula: wherein,

Cephalosporin having catechol group

This invention provides Cephem compounds having the formula: or an ester, a protected compound at the amino on the ring in the 7-side chain, a pharmaceutically acceptable salt, or a solvate thereof, a pharmaceutical composition thereof, and a method for treating a bacterial infectious disease with the compound, the ester, the protected compound, the salt, or the solvate thereof, wherein the symbols in the formula are defined in the specification. The compounds exhibit potent antimicrobial spectrum against a variety of bacteria including Gram negative bacteria and/or Gram positive bacteria, preferably beta-lactamase producing Gram negative bacteria, more preferably, multi-drug resistant microbials, in particular, Class B type metallo-beta-lactamase producing Gram negative bacteria, and still preferably extended-spectrum beta-lactamase (ESBL) producing bacteria. The compounds most preferably do not exhibit cross-resistance against known Cephem drugs or Carbapenem drugs.

Cephem compound having catechol group

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Toyonaka, Japan

Shinya Hisakawa