Toray Industries, Inc.

Shintaro Nishio

Kiyotaka Ohno

Hiroshi Nagase

Toshiya Takahashi

Atsushi Ohtake

Kazuhisa Matsumoto

Hisanori Wakita

Mamoru Ishikawa

Hajimu Kurumatani

Masato Mutoh

Shinya Ueno

Masafumi Isogaya

Masakazu Hattori

Kazuhiro Hoshi

Reiji Kasukawa

Hisao Nishiyama

Masayuki Miyata

Yuji Ueno

Shunji Tsukamoto

Hiroshi Koike

Agent for treating cor pulmonale

A composition for stimulating hair growth is described. The composition comprises as an effective ingredient a 5,6,7-trinor-4,8-inter-m-phenylene prostaglandin I.sub.2 derivative of the formula (I) or a pharmaceutically acceptable salt thereof.

Hair-growing composition

Antimetastasis agent of malignant tumors

Sulfonic acid derivative and its pharmaceutical application

Agent for treating hepatic diseases

2,5,6,7-tetranor-4,8-inter-m-phenylene PGI.sub.2, derivative,

Disclosed herein are novel prostaglandin I.sub.2 (PGI.sub.2) derivatives exhibiting excellent physiological activities, said derivatives being represented by the general formula: ##STR1## wherein R.sub.1, R.sub.2 and R.sub.3 are as defined herein.

2,5,6,7-tetranor-18,18,19,19-tetradehydro-4,8-inter-m-phenylene

Pharmaceutically useful compounds are 5,6,7-trinor-4,8-inter-m-phenylene PGI.sub.2 derivatives such as

5,6,7,-trinor-4,8-inter-m-phenylene 2-nor PGI.sub.2 derivatives and

Disclosed herein are novel prostaglandin I.sub.2 (PGI.sub.2) derivatives exhibiting excellent in vivo duration and activities, said derivatives being represented by the general formula: ##STR1## wherein R.sub.1, X, R.sub.2 and R.sub.3 are as defined herein.

2,5,6,7-tetranor-4,8-inter-m-phenylene PGI.sub.2 derivatives

Pharmaceutically useful compounds are 5,6,7-trinor-4,8-inter-m-phenylene PGI.sub.2 derivatives such as 5,6,7-trinor-4,8-inter-m-phenylene-13,14-didehydro PGI.sub.2, 5,6,7-trinor-4,8-inter-m-phenylene-16,16-dimethyl PGI.sub.2, 5,6,7-trinor-4,8-inter-m-phenylene-17-.alpha.-methyl-20-homo PGI.sub.2, 5,6,7-trinor-4,8-inter-m-phenylene-17,18,19,20-tetranor-16-phenoxy PGI.sub.2, 5,6,7-trinor-4,8-inter-m-phenylene-20-isopropylidene PGI.sub.2, 5,6,7-trinor-4,8-inter-(5-methyl-1,3-phenylene) PGI.sub.2, and 5,6,7-trinor-4,8-inter-m-phenylene-2,3-didehydro-16,17,18,19,20-pentanor-1 5-phenyl PGI.sub.2. They are useful in treatment of ulcers, thrombii and hypertension for example.

5,6,7,-Trinor-4,8-inter-m-phenylene PGI.sub.2 derivatives and

A compound of the formula ##STR1## wherein R.sup.1 is a pharmaceutically acceptable cation, hydrogen or n-alkyl of 1 to 12 carbon atoms; R.sup.2 is hydrogen, acyl of 2 to 10 carbon atoms or aroyl of 7 to 13 carbon atoms; R.sup.3 is hydrogen, acyl of 2 to 10 carbon atoms or aroyl of 7 to 13 carbon atoms; R.sup.4 is hydrogen, methyl or ethyl; R.sup.5 is n-alkyl of 1 to 5 carbon atoms; n is an integer of 0 to 4; A is --CH.sub.2 --CH.sub.2 -- or trans --CH.dbd.CH--; and X is --CH.sub.2 --CH.sub.2 -- or trans --CH.dbd.CH--. The compounds are useful in anti-ulcer, hypotensive and platelet aggregation inhibiting compositions.

5,6,7-Trinor-4,8-inter-m-phenylene prostaglandin I.sub.2 derivatives

Pharmaceutically useful compounds are 5,6,7-trinor-4,8-inter-m-phenylene PGI.sub.2 derivatives such as 5,6,7-trinor-4,8-inter-m-phenylene-16,17,18,19,20-pentanor-15-phenyl PGI.sub.2.

5,6,7-Trinor-4,8-inter-m-phenylene PGI.sub.2 derivatives

Growing community of inventors

Ebina, Japan

Shintaro Nishio