Mahle Filter Systems Japan Corporation

Waseda University

M Ahle International Gm Bh

Shintaro Ishigami

Yasuyuki Goto

Atsushi Nonaka

Daizo Ito

Noboru Inoue

Yoichi Nakao

Takashi Uchino

Shin-ichiro Kawazu

Satoshi Komiyama

[Problem to be Solved] To improve operability in detaching a sealing member. [Solution] A sealing structureaccording to the present invention includes a main body, a female thread partfixed to the main body, the female thread partbeing screwed into a discharge holeof a drain plug fastening partby the main bodybeing rotated in a normal rotation direction, and an elastically deformable arm part, one end of which is joined to the main body. A concave partis formed in the drain plug fastening partand a claw partis formed in the arm part. When the main bodyis rotated in the normal rotation direction, the arm partis elastically deformed while a part of the arm partslides on a top surfaceof the drain plug fastening partuntil the main bodyis rotated to a predetermined rotational position and, when the main bodyis rotated to the predetermined rotational position, the claw partfits in the concave partand the elastic deformation of the arm partis released, whereby the rotation of the main bodyfrom the predetermined rotational position is prevented. When the main bodyis rotated in a reverse rotation direction from the predetermined rotational position, the claw partslides on and climbs over a first wall partof the concave partwhile the arm partis elastically deformed, whereby the prevention of the rotation of the main bodyfrom the predetermined rotational position is released. The claw partor the concave partis formed such that, when the main bodyis rotated in the reverse rotation direction and the claw partis sliding on the first wall part, an angle A formed by a direction of force applied to the arm partfrom the drain plug fastening partand a straight line connecting a contact part of the claw partand the first wall partand a rotation center of the main bodyis smaller than 90 degrees when viewed in a rotation center direction of the main body

Sealing structure

A gasket inserted into a gasket groove is formed of a gasket main body part positioned in the middle part thereof and first/second end face projection parts each formed in a tapered shape, projecting from corresponding ones of the ends of the gasket main body part. Each of pressure-contact surfaces of the gasket main body part is formed as an arc-shaped surface having a convex shape projecting toward a corresponding one of the inner side surfaces of the gasket groove. The rate of the sum of the sectional areas of the first/second end face projection parts to the whole sectional area of the gasket is 30% or less, and the rate of the curvature radius of each of the tip end surfaces of the respective first/second end face projection parts to the maximum width dimension of the gasket main body part is 15% or less.

The object is to develop an antiprotozoal remedy having a novel mechanism of action. Provided is a compound represented by a chemical formula (1), a prodrug or a pharmaceutically acceptable salt thereof, wherein within the formula (1), Rrepresents R&#x2014; of formula (4) or R&#x2014; of formula (5); Rrepresents CHO&#x2014;, etc.; Rrepresents a hydrogen atom, CH&#x2014;C(&#x2550;O)&#x2014;, etc.; Rrepresents a hydrogen atom, CH&#x2014;C(&#x2550;O)&#x2014;, etc.; each of Rand Rindependently represents a hydrogen atom, a methyl group, etc.; Rrepresents &#x2014;CH&#x2014;, &#x2014;CH(&#x2014;OH)&#x2014; or &#x2014;C(&#x2550;O)&#x2014;; each of Rand Rindependently represents a hydrogen atom, a methyl group, etc.; Rrepresents &#x2014;CH&#x2014;, &#x2014;CH(&#x2014;OH)&#x2014; or &#x2014;C(&#x2550;0)&#x2014;; and Rrepresents a hydrogen atom, a hydroxyl group, a methyl group, etc.

Antiprotozoal compound derived from coelenterata

Growing community of inventors

Tokyo, Japan

Shintaro Ishigami