Toyo Boseki Kabushiki Kaisha

Shinsuke Kimata

Yoshihisa Kawamura

Shigeki Asano

Katsuhiko Mizuguchi

There is provided a reagent composition for the enzymatic determination of electrolytes, which has high solution stability enabling it to stand up to its distribution in the market as a liquid reagent, and which further has excellent quantitative reliability and accuracy. This is a reagent composition for the determination of electrolytes such as calcium or chloride ions, which contains: (a) inactive &agr;-amylase; (b) a chelating agent; (c) a substrate for &agr;-amylase; and (d) a cyclodextrin derivative, and which may optionally further contain an SH group containing compound or a salt thereof.

Reagent composition for determination of electrolytes

The present invention provides a combination of reagent compositions for measuring an electrolyte which are excellent in stability, precision and quantitativity and have high solution stability sufficient to withstand distribution. In the combination of the reagent compositions of the present invention, a chelating agent and an inactivated &agr;-amylase capable of being reversibly activated by the electrolyte are formulated separately from each other.

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Tsuruga, Japan

Shinsuke Kimata