Dainippon Pharmaceutical Company, Limited

Shinsaku Minami

Yoshiyuki Takase

Jun-ichi Matsumoto

Shinichi Nakamura

Masanao Shimizu

Shinsaku Mishio

Kazuyo Kawaguchi

Minoru Sugita

A penicillin compound of the formula ##STR1## wherein R is a formyl or acetyl group, and a nontoxic pharmaceutically acceptable salt thereof. The penicillin compound is prepared by (A) reacting a compound of the formula ##STR2## or its salt or its reactive derivative at the carboxyl group, with 6-.alpha.-amino-p-hydroxybenzylpenicillin or its salt or its derivative, or reacting a compound of the formula ##STR3## or its salt or its reactive derivative at the carboxyl group, with 6-aminopenicillanic acid or its salt or its derivative, (B) optionally hydrolyzing or catalytically hydrogenolyzing the reaction product, and (C) optionally converting the reaction product to a nontoxic pharmaceutically acceptable salt. The penicillin compound has low toxicity and superior antibacterial activity especially against bacteria of the genus Pseudomonas and is suitable for parenteral administration, especially for an intramuscular, intravenous or subcutaneous injection.

Novel penicillin compounds and process for preparation thereof

Piperazine derivatives of the following formula ##STR1## wherein A and B are a carbon atom or a nitrogen atom except the case where both A and B are nitrogen atoms,

Piperazine derivatives

This invention provides compounds of the following formula ##SPC1##

Antibacterial pharmaceutical compositions and processes for preparation

Growing community of inventors

Yamatokouriyama, Japan

Shinsaku Minami