Teikoku Seiyaku Co., Ltd.

Shinji Tanaka

Hirokazu Takahashi

Kenichi Hattori

Taiki Shibata

Akihiro Hasui

Makoto Takahashi

Ken-ichi Hattori

Atsuhiko Shiraishi

Kensuke Murata

Ken-Ichi Hattori

The present invention verifies a method of reducing skin irritation (particularly, cumulative skin irritation) caused by transdermal administration of a local anesthetic using iontophoresis, and provides an electrode pad for relief from a puncture pain which is safe not only at single administration but also at repeated administrations. The electrode pad comprises a base sheet; an electrode placed on the base sheet; an adhesive sheet placed on the base sheet and having an opening, within which the electrode being exposed; and a medicament reservoir containing a local anesthetic and placed in the opening of the adhesive sheet while being in contact with the electrode. An inner peripheral surface of the opening of the adhesive sheet and an outer peripheral surface of the medicament reservoir are prevented from coming into contact with human skin while contacting with each other, and thereby skin irritation is reduced.

Electrode pad used for iontophoresis treatment

The present invention provides a tolterodine-containing patch in which an adhesive layer is laminated on a backing, characterized in that the adhesive layer is obtainable by adding tolterodine to an adhesive base comprising a rubber adhesive, a tackifier resin, and a softener, wherein the tolterodine is present in the form of a free base in the adhesive base.

Tolterodine-containing adhesive patch

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Kagawa, Japan

Shinji Tanaka