Nof Corporation

Institute for Advanced Skin Research Inc.

Other

Tabata, Yasuhiko

Shinji Tanaka

Hiroshi Doi

Noboru Yamamoto

Ken Suzuki

Atsuhiko Ogura

Kenshiro Shuto

Akio Hayashi

Kazuhiko Ishihara

Nobuo Nakabayashi

Nobuyuki Sakamoto

Kenji Kato

Shujiro Sakaki

Shigeru Kitano

Yoshikazu Nakashima

Yasuhiko Tabata

Tatsuo Ouchi

Hiroshi Iwasaki

Yuichi Ohya

Koji Sakaguchi

Yoshikazu 20-201 Azanakamichi Nakashima

The present invention relates to a triblock copolymer, that is multipurpose yet has sufficient properties particularly for medical applications, and is useful as a material having excellent flexibility and water absorbability, as well as to a method for producing the same, and a biocompatible material. The copolymer of the present invention is composed of segments Aand Aeach composed of a polymer having a depsipeptide unit, such as a segment selected from a homopolymer of depsipeptide or a copolymer of lactide and depsipeptide, and segment B composed of polyalkylene glycol, such as PEG, and is a A-B-Atriblock copolymer having a number average molecular weight of 8000 to 500000. The biocompatible material of the present invention contains the triblock copolymer as a main component, and may be used as a tissue anti-adhesion barrier.

Triblock copolymer, method for producing the same, and biocompatible material

A novel A-B-Apolymer having a number average molecular weight of 10000 to 100000 is provided that has excellent bioabsorbability so as to disappear in a predetermined period of time even when embedded in a large amount in the body, has good kinetic properties, and is useful for preparing tissue anti-adhesion films. This polymer is composed of segments Aand Aeach having at least either of modified and unmodified amino acid groups, and segment B composed of PEG having a number average molecular weight of 8000 to 50000. The polymer contains both the modified and unmodified amino acid groups, the content of the modified amino acids is 20 to 85 mol % of all the amino acids in the polymer, and segment Ais bonded to one end of segment B and segment Ais bonded to the other end of segment B.

Polymer, bioabsorbable material and film for preventing tissue fusion

A composition for hydrogels which comprises (A1) a copolymer which comprises 25 to 97 mol % of unit (a) derived from a compound represented by formula (1) and 3 to 75 mol % of unit (b) derived from a monomer represented by formula (2) and is soluble in aqueous media and (B) a polymer which has hydrophilic groups such as hydroxyl or carboxyl groups and is soluble in aqueous media; and a hydrogel comprising the composition. (X represents a divalent organic residue; Y represents alkyleneoxy, etc.; Z, R, R, R, R, and Leach represents hydrogen, etc.; and Lrepresents &#x2014;CH&#x2014;, etc.)

Composition for hydrogel, hydrogel and use thereof

A wound-covering agent containing a polymer having a group represented by formula (I) (wherein R , R and R are the same or different and each represents hydrogen atom or C alkyl, and m is an integer of 2 to 4); a wound-covering material containing the preparation; and a method of wound healing which comprises the step of covering the wound of a subject with the wound-covering material to protect the wound.

Wound-covering preparation, wound-covering material, and method of wound healing

A polymer having a satisfactory balance between in vivo degradability and satisfactory mechanical properties, which is an A BA type polymer comprising a segment A and a segment A each having a modified amino acid and a segment B consisting of polyethylene glycol with a number-average molecular weight of 8000 or higher bonded at one end to the segment A and at the other end to the segment A , and has a number-average molecular weight of 10000 to 600000; an in vivo degradable material which comprises the polymer; and a film for preventing tissue adhesion, an artificial dura mater, a suture, an implant preparation, or a sustained-release drug base each comprising the degradable material.

Polymer, in vivo degradable material, and use

Skin activator with glycosaminoglycan production-accelerating effect

Growing community of inventors

Tsukuba, Japan

Shinji Tanaka