Shionogi & Company Limited

Sumitomo Electric Industries, Limited

The Tokyo Electric Power Company, Incorporated

Other

Shionogi Company Limited

Shinji Suzuki

Kazuo Ueda

Akira Yukimasa

Akira Kato

Naotake Kobayashi

Akihiro Hori

Naohiro Itoh

Gaku Sakaguchi

Yasuhiko Kanda

Hidekazu Haraguchi

Ken Yasui

Yuji Koriyama

Yuuji Kooriyama

Hideyuki Takenaka

Yukio Tada

Tatsuhiko Ueno

Sae Matsumoto

Chiaki Fujikoshi

Michio Masuko

Yoshizo Shibano

Takami Murashi

Toshikazu Ohtsuka

Yuusuke Tamura

Shuji Yonezawa

Yoshinobu Kobayashi

Seiji Hattori

Akihide Kasukawa

Naoki Tsuno

Junichi Doi

Hiroki Yamaguchi

Hidekazu Tanaka

Motohiro Fujiu

Genta Tadano

Takatsugu Inoue

Ken-ichi Kusakabe

Yusuke Ichihashi

Hiroshi Sonobe

Akio Tani

Masafumi Akehi

Yuusuki Tamura

Hiromi Kudo

The present invention provides a compound which has an effect of inhibiting amyloid &#xdf;production, especially an effect of inhibiting BACE1, and which is useful as a therapeutic or prophylactic agent for diseases induced by production, secretion and/or deposition of amyloid &#xdf;proteins. A compound of Formula (I) wherein 

Tetrahydropyranooxazine derivatives having selective BACE1 inhibitory activity

The present invention is related to a compound represented by formula (I) wherein &#x2014;X&#x2014; is &#x2014;NH&#x2014; or &#x2014;S&#x2014;; &#x2014;Z&#x2014; is &#x2014;O&#x2014; or &#x2014;S&#x2014;; R, Rand Rare each independently a hydrogen atom, substituted or unsubstituted alkyl, or the like; Ris a cyano, substituted or unsubstituted amino, or the like; Ris each independently a halogen; b is 0 or 1; or a pharmaceutically acceptable salt thereof, or a pharmaceutical composition comprising thereof.

Aromatic heterocyclylamine derivative having TRPV4-inhibiting activity

A composition having BACE 1 inhibitory activity containing a compound represented by the formula (I): 

Aminodihydrothiazine derivatives

A pharmaceutical composition for treating Alzheimer's disease containing a compound represented by the general formula (I): 

Pharmaceutical composition for treating alzheimer's disease

This invention provides a compound of the formula (I): wherein the ring A is an optionally substituted carbocyclic group or an optionally substituted heterocyclic group; Ris optionally substituted lower alkyl, optionally substituted lower alkenyl, optionally substituted lower alkynyl; Rand Rare each independently hydrogen, optionally substituted lower alkyl or optionally substituted acyl; R, R, Rand Rare each independently hydrogen, halogen, hydroxy or optionally substituted lower alkyl etc.;a pharmaceutically acceptable salt or solvate thereof,which is useful for treating diseases induced by production, secretion and/or deposition of amyloid &#x3b2; protein.

Aminodihydrothiazine derivatives substituted with a cyclic group

A composition having BACE 1 inhibitory activity containing a compound represented by the general formula (I): 

A composition having BACE 1 inhibitory activity containing a compound represented by the formula (I): wherein ring A is an optionally substituted heterocyclic group;E is lower alkylene;X is S;Ris a hydrogen atom or lower alkyl;R, R, R, R, Rand Ris each independently a hydrogen atom, halogen, or hydroxy etc.;n and m are each independently an integer of 0 to 3;n+m is an integer of 0 to 3;Ris a hydrogen atom or substituted lower alkyl;or its pharmaceutically acceptable salt thereof.

This invention provides a compound of the formula (I): 

A composition having BACE 1 inhibitory activity containing a compound represented by the general formula (I): wherein ring A is an optionally substituted carbocyclic group or an optionally substituted heterocyclic group;

Pyrimidine derivatives having antitumor effect

N-oxyl compounds, process for the preparation thereof, and process for inhibiting the polymerization of vinyl monomers with the same

An &agr;-substituted phenylacetic acid derivative useful as an agricultural fungicide, represented by general formula (I), or a salt thereof, a process for producing the same, an intermediate for the production thereof, and an agricultural fungicide containing the same as the active ingredient, wherein R,represents halogen, alkyl, OH, alkylthio, alkylsulfinyl, alkylsulfonyl, amino or nitro; Q represents aryl, heterocycle, mono- or disubstituted methyleneamino, (substituted amino-)methyl, alkyl, alkenyl, alkynyl, substituted carbonyl or substituted sulfonyl; X represents hydrogen, halogen, alkyl or OH; Y represents OH, alkylthio or amino; Z represents oxygen or sulfur; M represents oxygen, S(O)i (i being 0, 1 or 2), NR,(R,being hydrogen, alkyl or acyl) or a single bond; and n represents 0, 1 or 2.

&agr;-substituted phenylacetic acid derivative, its production and agricultural fungicide containing it

.alpha.-substituted phenylacetic acid derivative, its production and

Growing community of inventors

Osaka, Japan

Shinji Suzuki