Fujisawa Pharmaceutical Company, Ltd.

Astellas Pharma Gmbh

Shinji Shigenaga

Masaaki Matsuo

Hiroshi Matsuda

Takashi Manabe

Nobukiyo Konishi

Hiroshi Miyake

Daijiro Hagiwara

Kazuhiko Take

Kazuo Okumura

Tadashi Terasaka

Hidenori Azami

Kenji Murano

Yoshiteru Eikyu

Kazuo Nakai

Masataka Morita

Junya Ishida

Hiroaki Nishimura

Natsuko Kayakiri

Chiyoshi Kasahara

Norihiro Igari

Hiroshi Sasaki

This invention relates to piperazine derivatives of the formula: wherein each symbol is as defined in the description, and its pharmaceutically acceptable salt, to processes for preparation thereof, to pharmaceutical composition comprising the same, and to a use of the same for treating or preventing Tachykinin-mediated diseases in human being or animals.

Piperazine derivatives

This invention relates to piperazine derivatives of the formula:wherein each symbol is as defined in the description, and its pharmaceutically acceptable salt, to processes for preparation thereof, to pharmaceutical composition comprising the same, and to a use of the same for treating or preventing Tachykinin-mediated diseases in human being or animals.

Aroyl-piperazine derivatives, their preparation and their use as tachykinin antagonists

A compound of the formula (I): in which Z, R , R , R , R , R , R , R and R are each as defined in the description, or a salt thereof. The object compound of the present invention has pharmacological activities such as Tachykinin antagonism, and is useful for manufacture of a medicament for treating or preventing Tachykinin-mediated diseases.

Benzhydryl derivatives

Piperazine derivatives as tachykinin antagonists

Thiazolylbenzofuran derivatives and pharmaceutical compositions

A piperazine compound of the formula: ##STR1## wherein: X is carbonyl or sulfonyl;

A piperazine compound of the formula: ##STR1## wherein: X is carbonyl or sulfonyl; Y is a direct bond or lower alkylene; and R.sub.1, R.sub.2, R.sub.3, R.sub.4 are as defined herein. The compounds are advantageously used as Tachykinin antagonists in the treatment of respiratory diseases, ophthalmic diseases and inflammatory diseases, for example.

Quinolylbenzofuran derivatives as leukotriene antagonists

Compounds of the formula: ##STR1## wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4, A, X and Y are as defined and pharmaceutically acceptable salts thereof; which have activities as leukotriene and Slow Reacting Substance of Anaphalaxis (SRS-a) antagonists or inhibitors, to processes for preparation thereof, to a pharmaceutical composition comprising the same, and to methods of using the same therapeutically in the prevention and/or treatment of allergy or inflamation in human beings or animals.

Thiazolylbenzofuran derivatives and pharmaceutical composition

The invention relates to novel indolylpiperidine compounds useful in the treatment of allergic disease and inflammation.

Indolylpiperidine compounds, processes for the preparation thereof and

The invention relates to new compounds, of antiallergic activity, of the formula: ##STR1## wherein R.sup.1 is aryl substituted with substituent(s) selected from the group consisting of hydroxy, protected hydroxy, halogen and lower alkoxy, A is lower alkylene, and B is lower alkenylene, or a pharmaceutically acceptable salt thereof.

A thiazole compound of the formula: ##STR1## wherein R.sup.1 is amino or acylamino,

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Kobe, Japan

Shinji Shigenaga