Senju Pharmaceutical Co., Ltd.

Shinji Ohmori

Kazumi Ogata

Takahiro Sakaue

Hideki Tsuruoka

Yuuichi Isowaki

Yasuko Umegaki

Yoshimasa Abe

An antiinflammatory, antiallergic or hepatic disorders inhibitory agent containing a compound of the following formula or a pharmaceutically acceptable salt thereof as an active ingredient ##STR1## (wherein n represents 0 or 1; R.sub.1 means hydrogen or an alkyl group; R.sub.2 and R.sub.3 are the same or different and independently mean a hydroxyl group, a lower alkoxy group or an amino group or R.sub.2 and R.sub.3 together form an imino group; provided that R.sub.1 means an alkyl group where n=0 and R.sub.2 and R.sub.3 are the same or different and independently mean a hydroxyl group or a lower alkoxy group).

Glutathione derivatives

This invention relates to an intraocular irrigating composition containing a compound of the following formula or a pharmacologically acceptable salt thereof ##STR1## wherein R.sub.1 and R.sub.2 are the same or different and each represents a hydrogen atom or a methyl group. The glutathione derivative contained in the intraocular irrigating solution of this invention is not only effective in protecting the intraocular tissues on the occasion of ophthalmic surgery but effectively inhibits precipitation of the calcium contained. Therefore, the intraocular irrigating solution of this invention is very stable and can be used with advantage in various kinds of ophthalmic surgery such as cataract surgery and transplantation of the cornea, iris and vitreous body.

Method of inhibiting calcium precipitation in an intraocular irrigating

A method of lowering lipids is disclosed wherein a patient is administered a lipid metabolism improving composition characterized by comprising a compound of the following formula: ##STR1## wherein R.sub.1 represents a hydrogen atom or a lower alkyl group; R.sub.2 and R.sub.3 are the same or different and each represents a hydroxyl group, a lower alkoxy group or an amino group, or a pharmacologically acceptable salt thereof as an active ingredient. Since the compound of the present invention lowers blood triglyceride, cholesterol and .beta.-lipoprotein levels, it is of value for ameliorating hyperlipidemia in arteriosclerotic diseases, e.g. myocardinal infarction, angina pectoris, cerebral infarction, cerebral arteriosclerosis, etc., nephrosis, hypertension, diabetes, obesity and other diseases, and prevention of various circulatory diseases.

Method of lowering lipids

Glutathione-S-lower fatty acid derivative

Antihepatopathic composition

The invention provides an anticataract composition containing a compound of the following formula ##STR1## [wherein Rs are the same or different and each means a hydrogen atom or a lower alkyl group] or a pharmacologically acceptable salt thereof. The anticataract composition of this invention is useful for the prevention and treatment of various types of cataract including senile cataract and diabetic cataract.

Anticataract composition

The present invention relates to a useful antiinflammatory and/or antiallergic composition comprising a compound of the formula: ##STR1## (wherein the R's are same or different and each means a hydrogen atom or lower alkyl group) or a pharmaceutically acceptable salt thereof as an active ingredient.

Antiinflammatory and/or antiallergic methods

The present invention relates to a useful antihepatopathic composition comprising a compound of the formula: ##STR1## (wherein the R groups are the same or different and each means a hydrogen atom or a lower alkyl group) or a pharmaceutically acceptable salt thereof as an active ingredient.

Growing community of inventors

Okayama, Japan

Shinji Ohmori