Otsuka Pharmaceutical Company, Limited

Shinji Nishitani

Shinichi Ishikawa

Shunichiro Sumida

Seiji Sato

Kazumi Kondo

Masahiro Murakami

Satoshi Hayakawa

Hitoshi Tone

Shigeharu Tamada

Youichi Taniguchi

Yoshimasa Nakano

Yoshihiko Ito

Katsumi Tamura

Junichi Minamikawa

Hideaki Sato

Yasumitsu Tamura

Tomoyuki Kawaguchi

Hiromichi Fujioka

Katsuhide Matoba

Toshinori Kaneyasu

Yoshiaki Manabe

Junichiro Otsubo

Masanobu Kano

Yasuyuki Kita

Shuji Akai

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The novel indole derivatives and salts thereof represented by the general formula (1) ##STR1## possess, for example, an inhibitory effect against superoxide (O.sub.2.sup.-) released from the macrophage cells of guinea pig by stimulation and an anti-albuminuria activity against Masugi nephritis, and are useful in various clinical fields as an agent for preventing and treating diseases and cases associated with the above superoxide radical, for example, autoimmune diseases (e.g. rheumatism), arteriosclerosis, ischemic disease, ischemic encephalopathia, hepatic insufficiency and renal insufficiency, and also as an agent for preventing and treating nephritis.

Indole derivatives

Process for preparing dihydropyridine derivatives and salts and esters thereof represented by the general formula ##STR1## from a phenyl derivative and an enamine derivative in which the phenyl derivative is prepared by reacting a compound of the formula ##STR2## with a compound of the formula ##STR3## in the presence of an aromatic amine selected from o-, m-, p- anisidine; m-, p-toluidine; p-chloroaniline; aniline and o-phenetidine.

Process for preparing novel dihydropyridine derivatives

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Tokushima, Japan

Shinji Nishitani