Kyowa Hakko Kogyo Co., Ltd.

Kyowa Hakko Kirin Co., Limited

Shinji Nara

Yutaka Kanda

Yukimasa Shiotsu

Shiro Akinaga

Shiro Soga

Takayuki Nakashima

Hiroshi Nakagawa

Jiro Kajita

Keiko Kawashima

Hiromi Ando

Yoshinori Yamashita

Fumihiko Kanai

Tomoki Naoe

Hitoshi Kiyoi

Yoshihisa Ohta

Jun-ichi Saito

Motoki Miyama

Hiroshi Umehara

Rieko Nakatsu

Takeshi Takahashi

Tsutomu Akama

Yutaka Saitoh

Akira Asai

Tamio Mizukami

Timothy A Grese

Mitsunobu Hara

Shun-ichi Ikeda

Tsutomu Agatsuma

Douglas Linn Gernert

Yushi Kitamura

Masayo Suzuki

Takamasa Sugita

Hisashi Tagaya

Jun Eishima

Tomoyuki Nakazato

Hiroaki Nakamura

The present invention provides a compound represented by Formula (I): [wherein Rrepresents CONRR(wherein Rand Rmay be the same or different and each represents a hydrogen atom, substituted or unsubstituted lower alkyl, substituted or unsubstituted aryl, substituted or unsubstituted ararkyl or a substituted or unsubstituted heterocyclic group, or Rand Rare combined together with the adjacent nitrogen atom thereto to form a substituted or unsubstituted heterocyclic group) or the like,Rrepresents a hydrogen atom, CONRR(wherein Rand Rmay be the same or different and each represents a hydrogen atom, substituted or unsubstituted lower alkyl, substituted or unsubstituted aryl, substituted or unsubstituted ararkyl or a substituted or unsubstituted heterocyclic group, or Rand Rare combined together with the adjacent nitrogen atom thereto to form a substituted or unsubstituted heterocyclic group), NRR(wherein Rand Rmay be the same or different and each represents a hydrogen atom, substituted or unsubstituted lower alkyl, substituted or unsubstituted lower alkanoyl, substituted or unsubstituted aroyl, substituted or unsubstituted heteroaroyl, substituted or unsubstituted ararkyl, substituted or unsubstituted lower alkylsulfonyl or substituted or unsubstituted lower arylsulfonyl) or the like].

Indazole derivatives

The present invention provides Hsp90 family protein inhibitors comprising, as an active ingredient, a benzoyl compound represented by general formula (I): (wherein n represents an integer of 0 to 10; Rrepresents substituted or unsubstituted lower alkoxy, substituted or unsubstituted lower alkoxycarbonyl, CONRRor the like; Rrepresents substituted or unsubstituted aryl, a substituted or unsubstituted aromatic heterocyclic group or the like; Rand R, which may be the same or different, each represent a hydrogen atom, substituted or unsubstituted lower alkyl, substituted or unsubstituted lower alkenyl or the like; and Rand R, which may be the same or different, each represent a hydrogen atom, halogen, substituted or unsubstituted lower alkyl, substituted or unsubstituted aryl or the like) or a prodrug thereof, or a pharmaceutically acceptable salt of said benzoyl compound or said prodrug.

Hsp90 family protein inhibitors

The present invention provides a type I insulin-like growth factor receptor (IGF-1R) inhibitor comprising, as an active ingredient, an indazole derivative represented by Formula (I): {wherein Rrepresents &#x2014;NRR[wherein Rrepresents a hydrogen atom or the like, Rrepresents substituted or unsubstituted lower alkyl, &#x2014;C(&#x2550;O)R(wherein Rrepresents substituted or unsubstituted lower alkyl, substituted or unsubstituted aryl or the like), or the like], or the like, and Rand Rmay be the same or different and each represents a hydrogen atom, hydroxy, substituted or unsubstituted lower alkoxy, or the like} or a pharmaceutically acceptable salt thereof, and the like.

IGF-1R inhibitor

(wherein n is an integer of 0 to 10; Rrepresents substituted or unsubstituted lower alkyl, substituted or unsubstituted lower alkoxy, substituted or unsubstituted cycloalkyl, substituted or unsubstituted lower alkoxycarbonyl, substituted or unsubstituted heterocyclic-alkyl, substituted or unsubstituted aryl, &#x2014;CONRR, &#x2014;NRR, etc.; Rrepresents substituted or unsubstituted aryl or a substituted or unsubstituted heterocyclic group, etc.; Rand Rmay be the same or different, each represent a hydrogen atom, substituted or unsubstituted lower alkyl, etc.; Rand Rmay be the same or different, each represent a hydrogen atom, halogen, substituted or unsubstituted lower alkyl, etc.) Provided are an Hsp90 family protein inhibitor comprising, as an active ingredient, a benzene derivative of formula (I) or a prodrug thereof or a pharmaceutically-acceptable salt thereof, etc.

The present invention provides a compound represented by Formula (I): [wherein Rrepresents CONRR(wherein Rand Rmay be the same or different and each represents a hydrogen atom, substituted or unsubstituted lower alkyl, substituted or unsubstituted aryl, substituted or unsubstituted ararkyl or a substituted or unsubstituted heterocyclic group, or Rand Rare combined together with the adjacent nitrogen atom thereto to form a substituted or unsubstituted heterocyclic group) or the like,

UCS 1025 derivatives having antitumor activity or antibacterial activity which are represented by formula (I):wherein Rrepresents hydrogen, lower alkyl, etc.; Rrepresents hydrogen, or is combined with Rto represent a bond, etc., or is combined with Rto represent &#x2014;O(C&#x2550;O)&#x2014;, etc.; Rrepresents hydrogen, etc., or is combined with Rto represent a bond, etc.; Rrepresents hydrogen, etc., or is combined with Rto represent &#x2014;(C&#x2550;O)O&#x2014;, etc.; Rrepresents hydrogen or is combined with Rto represent a bond; Rrepresents hydrogen, etc., or is combined with Rto represent a bond; Rrepresents hydrogen or is combined with Rto represent &#x2550;O; Rrepresents hydroxy or is combined with Rto represent &#x2550;O;represents a single bond or a double bond, and a represents a single bond (two carbon atoms to which a is bound are combined to form a single bond) or an oxygen atom, or pharmaceutically acceptable salts thereof.

UCS1025 derivatives

This invention relates to substituted piperidine derivatives having at least one six-membered ring substituent. The piperidine derivatives exhibit antitumor activity and are useful as pharmaceuticals such as an antitumor agent.

Piperidine derivatives

Growing community of inventors

Sunto-gun, Japan

Shinji Nara