Bristol-myers Squibb Compnay

Bristol-myers Squibb

Shinji Masuyoshi

Hajime Kamachi

Kiyoto Imae

Takaaki Okita

Minoru Hirano

Takayuki Naito

Seiji Iimura

Disclosed are novel pradimicin compounds which possess antifungal activity and, preferably, improved water solubility. The compounds of the invention are prepared by modifying the 4&prime;-amino or 4&prime;-alkylamino moieties of known pradimicin compounds.

Pradimicin compounds

Disclosed are novel pradimicin compounds which possess antifungal activity and, preferably, improved water solubility. The compounds of the invention are prepared by modifying the 4'-amino or 4'-alkylamino moieties of known pradimicin compounds.

The present invention relates to new cephalosporins of the formula ##STR1## wherein R.sup.1 and R.sup.2 are hydrogen or carboxy, with the proviso that both cannot be the same;

Antibiotic C-7 catechol-substituted cephalosporin compounds,

This invention relates to novel cephalosporin derivatives of the formula ##STR1## wherein R.sup.1 is hydrogen, a straight, branched, or cyclic lower alkyl group having up to six carbon atoms or a radical of the formula ##STR2## in which R.sup.3 and R.sup.4 are each independently hydrogen, methyl or ethyl, or R.sup.3 and R.sup.4, taken together with the carbon atom to which they are attached, may be a cycloalkylidene ring containing from 3 to 5 carbon atoms;

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Yokohama, Japan

Shinji Masuyoshi