Sanwa Kagaku Kenkyusho Co., Ltd.

Shinji Makino

Yutaka Baba

Ryoji Noyori

Yoshihiro Hayakawa

Process for the preparation of tropane alkaloids, more particularly of N-acyl-dehydronortropinones, dehydrotropine and tropine. The compounds can be prepared by cyclocoupling N-acyl-pyrrole with .alpha.,.alpha.'-halogenoketone in the presence of a reducing agent and, if necessary, subjecting the resulting N-acyl-dehydronortropinone to either partial reduction and then stereo-selective reduction, or stereo-selective reduction and then partial reduction.

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Hazu, Japan

Shinji Makino