Takeda Pharmaceutical Company Limited

Shinji Kawaguchi

Mitsuhisa Yamano

Mitsutaka Goto

Masatoshi Yamada

Jun-ichi Kawakami

The present invention provides a novel ligand represented by the following formula and a novel transition metal complex having the ligand, which shows superior enantioselectivity and catalytic efficiency, particularly high catalyst activity, in various asymmetric synthesis reactions. A transition metal complex having, as a ligand, a compound represented by the formula wherein Ris a hydrogen atom or a Calkyl group optionally having substituent(s), and Rand Rare each a Calkyl group optionally having substituent(s), or the formula is a group represented by the formula wherein ring B is a 3- to 8-membered ring optionally having substituent(s).

Diphosphine ligand and transition metal complex using the same

A transition metal complex having 2,2'-bis[bis(3,5-di-tert-butyl-4-methoxyphenyl)phosphino]-1,1&#x2032;-binaphthyl as a ligand. The presence of the transition metal complex in the reaction system of an asymmetric reaction system allows the preparation of an objective compound having an objective absolute configuration with improved efficiency.

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Osaka, Japan

Shinji Kawaguchi