Daiichi Pharmaceutical Co., Ltd.

Other

Kabushiki Kaisha Yakult Honsha

Shinji Kamihara

Shigeru Noguchi

Kazuaki Kanai

Hirofumi Terasawa

Hiroaki Kitaoka

Tatsuya Terada

Toshifumi Akiba

Yusuke Yukimoto

Keiji Uchiyama

Tsutomu Ebata

Takanobu Ikeya

Tohru Kaneuchi

Hirofumi Kawanishi

Condensed-hexacyclic compounds and a process therefor

Process for the preparation of tetrahydroindolizines

Described is a process for the preparation of Compound (7) in accordance with the following reaction scheme by reacting Compound (5) with ethylene glycol in a solvent in the presence of a Lewis acid, thereby obtaining Compound (6), and then reacting the resulting compound with a carbonate diester in a solvent in the presence of a metal alkoxide (R,, R,each represents a C,alkyl group or the like and R,represents H or C,alkyl group).

Process for the preparation of tetrahydro-indolizines

Aminotetralone derivatives and preparation process thereof

Selective dehalogenation process

A process for preparing a 2-(1-pyrrolidinyl)acetamide derivative useful as a cerebral function improving agent is disclosed, comprising reacting a halogenoacetamide derivative with substituted or unsubstituted 2-pyrrolidinone, the halogenoacetamide derivative being prepared by reacting an amine and a halogenoacetyl chloride. High yields of the intermediate compound as well as the final product are attained at low cost.

Process for preparing pyrrolidinylacetamide derivatives

Growing community of inventors

Tokyo, Japan

Shinji Kamihara