Shiseido Company, Limited

Shinji Inomata

Koji Kobayashi

Masaru Suetsugu

Toshii Iida

Okihiko Sakamoto

Makoto Tsunenaga

Kiyotaka Kojima

Mikiko Kaminuma

Seiichi Yoshida

Hiroshi Fukui

Satoshi Amano

Mineyuki Yokoyama

Kenichi Umishio

Shunsuke Iriyama

Takuya Hiruma

Eijiro Adachi

Atsushi Takimoto

Shoko Yamaguchi

Yuji Katsuta

Yukiko Matsunaga

Keiko Takada

Kazuo Komatsu

Kazuo Komatu

The present invention relates to a method for producing artificial skin, comprising: adding a matrix metalloproteinase inhibitor and a heparanase inhibitor to an artificial skin formation culture medium comprising human epidermal keratinocytes and human dermal fibroblasts, culturing the cells in the artificial skin formation culture medium, and forming artificial skin.

Artificial skin

The invention provides a parakeratosis inhibitor, pore-shrinking agent, or rough skin preventing/ameliorating agent that has a function such as parakeratosis inhibition, pore shrinkage, or rough skin-inhibition/abatement, poses no safety problems such as sensory irritation, and is very safe, and further provides an external composition for skin to which a compound having the above-mentioned function has been added. The parakeratosis inhibitor, pore-shrinking agent, or rough skin preventing/ameliorating agent comprises one or more compounds selected from the group consisting of &#x3b2;-alanine derivatives and salts thereof. The external composition for skin comprises the one or more compounds selected from the group consisting of &#x3b2;-alanine derivatives and salts thereof as the above-mentioned parakeratosis inhibitor, pore-shrinking agent, or rough skin preventing/ameliorating agent.

Parakeratosis inhibitor, pore-shrinking agent and external composition for skin

To provide a parakeratosis inhibitor, pore reducing agent and skin roughness preventing/ameliorating agent that exhibit capabilities of parakeratosis inhibition, pore reduction, skin roughness prevention/amelioration, etc., and further provide a skin preparation for external use having these capabilities. There are provide a parakeratosis inhibitor and a pore reducing agent each comprising at least one compound selected from the group consisting of a glycine derivative, an aminodicarboxylic acid derivative, an acylaminodicarboxylic acid derivative, a pyrrolidinecarboxylic acid derivative, a piperidinecarboxylic acid derivative, a hexamethyleneiminecarboxylic acid, a beta-alanine derivative and salts of these derivatives. Further, there are provided a parakeratosis inhibitor, a pore reducing agent and a skin roughness preventing/ameliorating agent each comprising at least one compound selected from the group consisting of specified glycine derivatives and salts thereof and specified aminosulfuric acid derivatives and salts thereof. Still further, there are provided skin preparations for external use comprising these compounds.

Parakeratosis inhibitor and skin preparation for external use

A method for production of artificial skin by administering matrix metalloproteinase inhibitor or matrix metalloproteinase inhibitor and matrix protein production promoting agent. The matrix metalloproteinase inhibitor is N-hydroxy-2(R)-[[(4-methoxyphenyl)sulfonyl](3-picolyl)amino]-3-methylbutanamide hydrochloride.

Method of production of artificial skin

A dithiazole compound or a salt thereof is disclosed. The compound inhibits matrix metalloprotease (MMPs) activity and can be used in pharmaceutical and cosmetic compositions for the treatment of skin conditions.

Dithiazole compounds, matrix metalloprotease inhibitors and external preparations for the skin

An azabicyclo compound (I) or a salt thereof in accordance with the present invention has an excellent inhibiting action on matrix metalloproteases (MMPs) activity, and is useful for pharmaceutical, cosmetic and skin external compositions. wherein R is H, alkyl, heteroalkyl, aryl, heteroaryl, arylalkyl, heteroarylalkyl, acyl, COOR, carbamoyl or SOR(wherein Rand Reach are alkyl, heteroalkyl, aryl, heteroaryl, arylalkyl or heteroarylalkyl); X is methylene, ethylene or propylene; and is a single bond or a double bond.

Azabicyclo compound matrix metalloprotease inhibitor and skin preparation

An agent for inducing flower bud formation in plants comprising an unsaturated fatty acid having an oxo group and a hydroxy group, a hydroperoxy group, or an oxo group, a hydroxy group, and a hydroperoxy group; a method for preparing said agent for inducing flower bud formation; and, a method for inducing flower bud formation using said agent for inducing flower bud formation are provided.

Agents for inducing flower bud formation

Flower initiation inducer

Growing community of inventors

Yokohama, Japan

Shinji Inomata