Eisai Company, Limited

Eisai R&d Management Co., Ltd.

Shinji Hatakeyama

Koichi Ito

Koki Kawano

Satoshi Nagato

Kohshi Ueno

Yoshihiko Norimine

Masataka Ueno

Takahisa Hanada

Yuichi Suzuki

Yoichi Iimura

Noboru Yamamoto

Hiroyuki Amino

Terence Smith

Makoto Ogo

Anthony John Groom

Leanne Rivers

Tetsuhiro Niidome

Tetsuyuki Teramoto

Makoto Komatsu

Toshihiko Kaneko

Noritaka Kitazawa

Akiharu Kajiwara

Teiji Kimura

Daisuke Shinmyo

Yoshio Urawa

Nobuyuki Kurusu

Hiroyuki Naka

Manami Kimura

Yoshihisa Kaneda

Yukie Yoshikawa

Tatsuto Fukushima

The present invention provides a novel compound having an excellent AMPA receptor inhibitory action and/or kainate inhibitory action. A compound represented by the following formula, a salt thereof or hydrates thereof.  In the formula, Q indicates NH, O or S; and R, R, R, Rand Rare the same as or different from each other and each indicates hydrogen atom, a halogen atom, a Calkyl group or a group represented by the formula &#x2014;X-A (wherein X indicates a single bond, an optionally substituted Calkylene group etc.; and A indicates an optionally substituted Caromatic hydrocarbocyclic group or 5- to 14-membered aromatic heterocyclic group etc.).

1,2-dihydropyridine compounds, manufacturing method thereof and use thereof

The present invention provides a novel compound having an excellent AMPA receptor inhibitory action and/or kainate inhibitory action. A compound represented by the following formula, a salt thereof or hydrates thereof. In the formula, Q indicates NH, O or S; and R, R, R, Rand Rare the same as or different from each other and each indicates hydrogen atom, a halogen atom, a Calkyl group or a group represented by the formula &#x2014;X-A (wherein X indicates a single bond, an optionally substituted Calkylene group etc.; and A indicates an optionally substituted Caromatic hydrocarbocyclic group or 5- to 14-membered aromatic heterocyclic group etc.).

1,2-dihydropyridine compounds, process for preparation of the same and use thereof

The present invention provides a novel compound having a superior calcium antagonism, in particular, a neuron-selective calcium antagonism. Namely, it provides a compound represented by the following formula, a salt thereof or a hydrate of them.In the formula, Ar indicates an optionally substituted 5- to 14-membered aromatic ring etc.; the ring A indicates any one ring selected from a piperazine, a homopiperazine, a piperidine and the like; the ring B indicates an optionally substituted Con hydrocarbon ring etc.; E indicates a single bond, a group represented by the formula &#x2014;CO&#x2014;, etc.; X indicates a single bond, an oxygen atom etc.; Rindicates a hydrogen atom, a halogen atom, a hydroxyl group etc.; and D, D, Wand Ware the same as or different from each other and each represents a single bond or an optionally substituted Calkylene chain.

Piperazine compound and pharmaceutical composition containing the compound

Heterodiazinone derivatives

N,N-substituted cyclic amine derivatives

Growing community of inventors

Ibaraki, Japan

Shinji Hatakeyama