Kyowa Hakko Kirin Co., Limited

Sony Corporation

Honda Motor Co., Ltd.

La Jolla Institute for Allergy and Immunology

Bridgestone Flowtech Corporation

Daido Steel Co., Ltd.

Kyowa Kirin Co., Ltd.

Kyowa Hakko Kirin

Shinichiro Kato

Kenji Mine

Takahiro Yokomatsu

Rachel Soloff Nugent

Shuichi Kikuchi

Hitoshi Yoshida

Michael Croft

Takahiro Miyazaki

Carl F Ware

Steven W Granger

Yuji Shishido

Kenichiro Yazawa

Tomoyuki Tahara

Toru Ujiie

Takeshi Wakabayashi

Hiroyuki Kaneta

Takashi Kano

Katsumi Sahoda

Makoto Hobo

Rongfang Wang

Isamu Saito

Sandra Rickert

Lilia Koriazova

Sumitaka Ogawa

Kazuhiko Ono

Daisuke Tabuchi

Hideo Takahashi

Takumi Makabe

Tsuyoshi Tsuda

Shane Crotty

Hiroyuki Osaki

Yoshihiro Takitani

Steve Granger

Keiichiro Kamiya

Hideki Matsuda

Hiroshi Kurata

Toshifumi Mikayama

Tadao Igarashi

Naoyuki Yamate

Toshiro Kobayashi

Yoshiyuki Imai

Akihito Ninomiya

Yoshinari Okada

Ayumi Yamazaki

Teruo Chiba

Yasushi Matsumura

Hiroaki Shibuya

Ayako Hatai

Paul Rogers

Aihua Song

Tetsuya Shimomura

Katsuya Yamaguchi

Hiroki Masuda

Shinpei Okazaki

Akira Ogitani

The invention provides antibodies that specifically bind to OX40 (CD134), referred to as OX40 antibodies, anti-OX40 or anti-OX40 antibodies. Invention antibodies that specifically bind to OX40 include mammalian (human, primate, etc.), humanized and chimeric anti-OX40 antibodies. Invention antibodies and antibody subsequences (fragments) that specifically bind to OX40 include purified and isolated antibodies, as well as pharmaceutical formulations thereof, are useful in various methods including treatment, screening and detection methods.

Human monoclonal antibody human CD134 (OX40) and methods of making and using same

A front wheel caliper bracket for supporting an axle is provided in a lower end portion of a front fork. A wheel speed sensor is mounted on the bracket. The wheel speed sensor includes a fixing section and a sensor section, and is mounted on a sensor mounting section of the bracket by a bolt. The sensor mounting section is integrally formed with a rotation regulating portion in a projecting fashion. When fastened by the bolt, a lateral part of the rotating wheel speed sensor comes into contact with the rotation regulating portion to regulate the rotation of the wheel speed sensor, so that the stress from the rotation regulating portion is not exerted directly on the sensor section.

Supporting structure of wheel speed sensor

In a vehicle including a pulse ring that rotates together with a wheel, a wheel speed sensor that has a detection portion close to the pulse ring, and a bracket that fixes the wheel speed sensor, a tubular protective wall surrounding the detection portion is provided on the bracket so that an end part, on the pulse ring side, of the protective wall is closer to the pulse ring than the detection portion of the wheel speed sensor is. This enables the wheel speed sensor to be protected without adding a special component.

Vehicle wheel speed sensor protection structure

Provided herein are antibodies that immunospecifically bind to an hLIGHT polypeptide; isolated nucleic acids encoding the antibodies; vectors and host cells comprising nucleic acids encoding the antibodies; methods of making the antibodies; and a method of treating a hLIGHT-mediated disease in a subject comprising administering to the subject the antibodies. In preferred embodiments, the anti-hLIGHT antibodies provided herein will ameliorate, neutralize or otherwise inhibit hLIGHT biological activity in vivo (e.g., the hLIGHT-mediated production or secretion of CCL20, IL-8 or RANTES from a cell expressing a hLIGHT receptor). Also provided herein is a method for the detection of hLIGHT in a sample as well as a method for ameliorating, neutralizing or otherwise inhibiting hLIGHT activity, e.g., in a human subject suffering from a disorder in which hLIGHT activity is detrimental.

Antagonistic human light-specific human monoclonal antibodies

The invention provides a carburized part which has excellent medium-cycle fatigue strength in particular subjected to surface-hardening treatment by carburization. The invention provides a carburized part including a carburized layer formed by performing carburizing treatment to a steel, the steel including, in terms of % by mass: 0.15% to 0.25% of C, 0.15% or less of Si, 0.4% to 1.1% of Mn, 0.8% to 1.4% of Cr, 0.25% to 0.55% of Mo, 0.015% or less of P, and 0.035% or less of S, with the remainder being Fe and unavoidable impurities, and the steel satisfying the following relation; 0.10&#x2266;[Mo]/(10[Si]+[Mn]+[Cr])&#x2266;0.40, in which [M] represents a content of element M in terms of % by mass.

Carburized part, method for manufacturing thereof, and steel for carburized part

Provided is a method of manufacturing a nitrocarburized crankshaft which is obtained by subjecting a bainitic microalloyed steel to a forging and a machining, and further subjecting the bainitic microalloyed steel to at least a strain releasing heat treatment and a subsequent nitrocarburizing treatment, the bainitic microalloyed steel containing, as essentially added elements, in terms of mass %: 0.10% to 0.40% of C; 0.10% to 1.0% of Si; 1.0% to 2.0% of Mn; 0.05% to 0.40% of Mo; and 0.05% to 0.40% of V, and the bainitic microalloyed steel optionally further containing, as arbitrarily added elements, in terms of mass %: 0.01% to 0.1% of S; 0.005% to 0.2% of Ti; 0.001% to 0.03% of Al; 0.50% or less of Cr; 0.5% or less of Cu; and 0.5% or less of Ni, with the balance being Fe and unavoidable impurities.

Nitrocarburized crankshaft and method of manufacturing the same

The invention relates to antibodies and subsequences thereof that specifically bind to poxvirus B5R envelope protein, antibodies and subsequences thereof that specifically bind to poxvirus H3L envelope protein, and combinations thereof.

Vaccinia virus H3L and B5R specific monoclonal antibodies and methods of making and using same

A nitrocarburized crankshaft member made of a steel that includes C in an amount by weight of 0.25 to 0.32% as a required element and an optional element that may be included, and Fe and inevitable impurities in a remaining portion. The steel-made crankshaft member mainly includes ferrite and perlite, wherein at least a portion of the steel surface thereof having a ferrite surface area of 50% or greater is imparted with a nitrocarburized hard layer. The nitrocarburized hard layer includes a surface compound layer suppressed to a thickness of 10 to 35 &#x3bc;m, and a nitrogen diffusion zone below the surface compound layer having a diffusion depth of 700 &#x3bc;m or greater. The steel includes C, Si, Mn, Cu, Ni, and Cr as the required elements and Mo, N, s-Al, and Ti as the optional elements.

Nitrocarburized crankshaft member and steel for nitrocarburized crankshafts

A bending load acting on a steering shaft only with a magnetostrictive torque sensor, without separately providing a sensor for detecting the bending moment. A storage unit stores, as an initial characteristic curve formed from initial detection values, a characteristic curve formed from detection values of each of a first detection coil and a second detection coil when only twisting torque is applied to a steering shaft. A bending load detector provided in an ECU detects a bending load amount acting on the steering shaft based on a difference between each detection value of the first and second detection coils and the initial detection value on the initial characteristic curve corresponding to the detection value.

Control unit for electric power steering device

The invention relates to a crankshaft member having high fatigue strength and good bending correctability, and its method of manufacture. The steel made crankshaft member mainly consists of a two-phase structure of ferrite and perlite. The steel includes C, Ni, Mn, and Cr as required elements and Si, Cu, Mo, Ti, V, Nb, Ca, and S as optional elements that may be included, in the amounts of C within the range of 0.20 to 0.50 wt %, Si within the range of 0 to 0.6 wt %, Mn within the range of 0.5 to 1.5 wt %, Cu within the range of 0 to 0.7 wt %, Ni within the range of 0.05 to 1.5 wt %, Cr within the range of 0.05 to 0.45 wt %, and Mo within the range of 0 to 0.5 wt % to satisfy the condition 115&#x2267;70C+8Si+23Mn+11Cu+128Cr+83Mo&#x2267;50. A portion of the member surface is provided at least with a hard nitride layer having an average hardness within the range of 300 to 450 HV. Lamellar spacing of the perlite is 0.3 &#x3bc;m or less.

Manufacturing method for a crankshaft member

The invention relates to antibodies and subsequences thereof that specifically bind to poxvirus B5R envelope protein, antibodies and subsequences thereof that specifically bind to pox virus H3L envelope protein, and combinations thereof.

Growing community of inventors

Chiba, Japan

Shinichiro Kato