Shiseido Company, Limited

Takasago International Corporation

Shinichiro Haze

Yoko Gozu

Mio Nakamura

Kazutoshi Sakurai

Jiro Kishimoto

Ohji Ifuku

Kentaro Kajiya

Takahiro Ishikawa

Yasuko Nakamura

Akira Ito

Mineyuki Yokoyama

Shoko Yamaguchi

Kenichi Umishio

Takashi Nishida

Atushi Joichi

Katsuyuki Yomogida

Takako Shibata

Yushi Terajima

Rumiko Fujiwara

Masako Katsuyama

Keiko Mori

Atsushi Joichi

Atsushi Jouichi

The purpose of this invention is to find a novel fragrance component effective for prevention or control of swelling, lymphedema, skin aging or obesity from the viewpoint of activation of lymph vessel function by promotion of the expression of VEGFC. This invention provides a swelling improving agent, lymph vessel activator and VEGFC production promoter characterized by containing one or a plurality of components selected from the group consisting of rose oxide, citronellyl acetate and niaouli oil.

VEGFC production promoter

The present invention provides a novel substance that promotes expression of filaggrin gene involved in improvement of the moisture retention function of skin. The inventors of the present invention found that expression of filaggrin gene fluctuates rhythmically over a roughly 24 hour cycle, screened candidate substances based on the time at which expression reaches a maximum following addition of the candidate substance, and identified zanthoxylum extract, 3-(1'-piperidine)propionic acid, geranium oil, cypress oil, rose oil, galvanum oil, pepper oil, basil oil, methyl-o-toluate, methyl anthranilate and dimethyl anthranilate as filaggrin gene expression promoting agents.

Filaggrin gene expression promoter

A method for promoting expression of a clock gene and/or a hyaluronic acid synthase gene in skin, comprising applying onto skin a composition comprising one kind or two kinds selected from lavender oil and eucalyptus oil, and an alkylene oxide derivative.

Expression promoting agent for clock gene and hyaluronic acid synthase gene

Provided is a novel drug capable of inhibiting excessive formation of melanin in skin and a skin whitening agent incorporated therewith. Phenylethyl cinnamate is incorporated as an active ingredient.

Melanin production inhibitor

A rose-like fragrance composition including methyl epijasmonate, provided that a natural jasmine fragrance containing methyl epijasmonate is excluded. The rose-like fragrance composition can also include 2-isopropyl-4-methyl thiazole.

Fragrance compositions

Provided is a fragrance composition having a natural rose aroma with freshness, sweetness, and softness, which is hardly reproduced by combining aroma components conventionally known as rose aromas. Also provided is a fragrance composition having excellent rose-like naturalness, freshness, and richness. More specifically, provided are: a fragrance composition, having added thereto 2-isopropyl-4-methylthiazole alone or in combination with rose oxide; a method of manufacturing the same; and a method of imparting an aroma to a fragrance composition, the method including adding 2-isopropyl-4-methylthiazole to a base fragrance composition having a rose-like aroma as a main aroma. Also provided are: a rose-like fragrance composition, having added thereto methyl epijasmonate alone or in combination with 2-isopropyl-4-methylthiazole; a method of manufacturing the same; and a method of imparting an aroma to a fragrance composition, the method including adding methyl epijasmonate alone or in combination with 2-isopropyl-4-methylthiazole to a base fragrance composition having a rose-like aroma as a main aroma.

A natural flavor or fragrance can be easily and effectively produced by using a &ldquo;unicellularized plant&rdquo;, obtained by unicellularizing, without destroying, the cells of a plant usable as a starting material for a natural flavor or fragrance, as a material for the natural flavor or fragrance and further applying an enzymatic treatment or chemical treatment or continuously heating the same, to thereby remarkably shorten the aging period for producing the natural flavor or fragrance, or by homogenizing a plant usable as the starting material quickly after harvesting to thereby promote the aging.

Process of production of natural flavor or fragrance

Escherichia coli characterized in that a capability thereof of forming acetate is at most one fifth that of wild type Escherichia coli, and a process for producing a useful substance by cultivating the Escherichia coli to a high density and recovering the substance

Microorganism having low acetate forming capability, and process for

A mutant strain having a glucose consumption rate is at most 1/4 that of wild type strains is provided. The mutant strain belongs to Escherichia, Bacillus, Pseudomonas, or Serratia; has a glucose consumption rate of at most one fourth that of the corresponding wild type strain, and the feedback repression by biotin is removed. Further, a process for producing biotins using this mutant strain is provided.

Growing community of inventors

Yokohama, Japan

Shinichiro Haze