Sankyo Company, Limited

Shinichi Sugawara

Hideo Nakao

Tetsuo Miyadera

Yukio Sugimura

Teruo Tanaka

Kimio Iino

Toshihiko Hashimoto

Tomoyuki Shibata

Koichi Fujimoto

Sadao Ishihara

Mitsuo Nagano

Eiji Ohki

Isamu Igarashi

Hiroaki Yanagisawa

Masakatsu Kaneko

Bunji Shimizu

Hiromichi Saeki

Akira Yoshida

Takeo Kobayashi

Sadao Oida

Tetsuo Hiraoka

Noboru Ishida

Teruo Hayashi

Compounds of formula (I): ##STR1## (wherein R.sup.1 is carboxy, --CONR.sup.4 R.sup.5, cyano or hydroxymethyl, and R.sup.2 and R.sup.3 are hydrogen, alkyl or substituted alkyl, R.sup.4 and R.sup.5 being hydrogen or a variety of groups) have good antibiotic activity and reduced renal toxicity.

Carbapenem compounds and use

Compounds of formula (I): ##STR1## wherein: R.sup.1 represents a lower alkyl group selected from methyl groups and ethyl groups;

7-(2-amin

Compounds of formula (I): ##STR1## in which: R.sup.1 represents a hydrogen atom, an alkyl group, an alkoxy group or various substituted alkyl groups;

2-penem-3-carboxylic acid derivatives and use

Compounds of formula (I): ##STR1## (wherein R.sup.1 represents a C.sub.1 -C.sub.4 alkyl or C.sub.1 -C.sub.3 alpha-hydroxyalkyl group;

Penem derivatives, and composition containing them

Compounds of formula (I): ##STR1## [wherein: R.sup.1 represents a hydrogen atom, an alkyl group, an alkoxy group or various substituted alkyl groups;

Carbapenem compounds, and compositions containing them

7-[2-(2-A

The compounds of the formula (I): ##STR1## wherein: R.sup.1 represents a hydrogen atom and

Cephalosporin derivative and antibiotic compositions

Penem-3-carboxylic acid derivatives of formula (I): ##STR1## (wherein: R.sup.1 represents a hydrogen atom, an alkyl group, an alkoxy group, a hydroxyalkyl group, an acyloxyalkyl group, an alkylsulphonyloxyalkyl group, an arylsulphonyloxyalkyl group or a trialkylsilyloxyalkyl group;

Penem-3-carboxylic acid derivatives

7-Oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid derivatives of formula (I): ##STR1## (in which:) R.sup.1 represents a hydrogen atom or an optionally substituted alkyl group;

7-Oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid derivatives, their

Novel cephalosporin derivatives having a (1-alkyl-1H-tetrazol-5-yl)vinyl group at the 3-position of the cephem nucleus and showing an excellent antibacterial activity are disclosed. A process for preparing the cephalosporin derivatives is also disclosed.

7-D-(-)-mandelamido-3-(1-methyl-1H-tetrazol-5-yl)vinyl-

A compound having the formula ##STR1## wherein Y represents a 2-carboxyethylthio group or a trifluoromethylthio group and a nontoxic pharmaceutically acceptable salt thereof are useful as antibacterial agents. They may be prepared by (a) reacting a compound having the formula ##STR2## wherein X.sub.1 represents a halogen atom with a compound having the formula

7-Methoxycephalosporin derivatives

A compound of the formula ##STR1## wherein A represents acetoxy group, carbamoyloxy group or (1-metyl-1H-tetrazol-5-yl)thio group and Y represents propargylthio group, azidomethylthio group, 2-hydroxyethylthio group, 3-isoxazolyloxy group, 3-isoxazolylthio group, methylsulfonyl group, ethylsulfonyl group, 2-cyanoethyl-sulfonyl group or sydnon-3-yl group and nontoxic pharmaceutically acceptable salts thereof are prepared by a process which comprises reacting a compound of the formula ##STR2## wherein R represents a protective group for a carboxyl group and A has the same meaning as defined above with a carboxylic acid of the formula

Cephalosporin derivatives

New derivatives of the antibiotic butirosin A having the formula: ##STR1## in which R is a radical of formula (II): ##STR2## and pharmaceutically acceptable acid addition salts thereof. The butirosin A derivatives of formula (I) can be prepared by reduction of a 5'-azido compound having the formula (III): ##STR3## in which R' is the same groups R or a group which, on reduction, gives a group of formula (II). The butirosin A derivatives of general formula (I) and pharmaceutically acceptable acid addition salts thereof are active against a broad spectrum of Gram-positive and Gram-negative bacteria, including some butirosin-resistant strains.

Aminoglycoside antibiotics

New derivative of butirosin A, 3', 4'-dideoxybutirosin A having not only broad antibacterial activities against gram-positive and -negative bacteria but also an activity against butirosin-resistant bacteria with a low toxicity. It is prepared from the corresponding 3', 4'-dideoxy-3'-eno derivative derived from butirosin A or a mixture of butirosins A and B by catalytic reduction.

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Hiromachi, Japan

Shinichi Sugawara