Snow Brand Milk Products Co., Ltd.

Shinichi Shimada

Masamichi Nakakoshi

Susumu Ishiguro

Motohide Seya

Masayuki Okue

Yuzo Yagi

Noboru Kawaguchi

Nobuo Ogane

Gosei Kawanishi

Shin Nomoto

Yasuyoshi Takeshita

Tadayoshi Koyama

Yasunari Saito

Yasunari Saitou

Akinori Wakaiki

Naomi Kito

Keiji Hayashi

Kunio Tomitsuka

Isoquinoline derivatives

Particular hexahydropyrano [3,2-b] [1,4] benzothiazine derivatives represented by the following general formula (I) or pharmaceutically acceptable acid-addition salts thereof. ##STR1## The compounds can facilitate the metabolic turnover of inositol phospholipids at a hippocampus playing an important part in memory, and improve cerebral function leading the memory. The compounds can be utilized as agents for activating brain metabolism and improving cerebral function.

Hexahydropyrano [3,2-B] [1,4] benzothiazine derivative

Novel alprenolol derivatives represented by the formula: ##STR1## wherein R is ##STR2## and hydrochlorides thereof are disclosed.

Alprenolol derivatives

Growing community of inventors

Utsunomiya, Japan

Shinichi Shimada