Kaneka Corporation

Shinichi Sakashita

Kunihiko Matsumura

Masaoki Goto

Kenji Fujii

Kazunori Hosoe

Katsuji Yamashita

Yasuhiro Saka

Takehiko Yamane

Mamoru Tsugawa

Norio Hirokawa

A regenerated collagen fiber is subjected to water-insolubilizing treatment with a monofunctional epoxy compound to produce a water-insolubilized regenerated collagen fiber which can substantially maintain the color and the high knot tenacity, inherent in the collagen. Where the monofunctional epoxy compound is an epihalohydrin, a regenerated collagen fiber can be treated with this epihalohydrin and a sulfur compound to produce a water-insolubilized regenerated collagen fiber which can be permanent-wave set. In addition, the water-insolubilized regenerated collagen fiber can be converted into a fiber which can be permanent-wave set, by introducing a disulfide linkage into carboxylic groups of the collagen, which remain unmodified by the insolubilizing treatment.

Method of producing water-insolubilized regenerated collagen fiber

The present invention provides a regenerated collagen fiber exhibiting a draping, luster and feel close to those of a natural protein fiber such as a human hair and capable of application of a permanent wave treatment, and a method of manufacturing the regenerated collagen fiber. The amino group and/or carboxyl group of the regenerated collagen is chemically modified to introduce a mercapto group and/or a disulfide linkage to the regenerated collagen. When subjected to a permanent wave treatment, the regenerated collagen fiber retains the waved shape.

Regenerated collagen fiber and method of manufacturing the same

A method for treating a digestive organ disease caused by the infection of Helicobacter, comprising administering a rifamycin derivative expressed by the formula (I), or a physiologically acceptable salt thereof ##STR1##

Treatment of disease caused by infection of Helicobacter

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Kobe, Japan

Shinichi Sakashita