Osaka University

Shinichi Miyake

Isao Fuke

Michiaki Takahashi

Masahide Ishibashi

Toyokazu Ishikawa

Toshiyuki Onishi

Hideo Goda

Takeshi Nabeshima

Kouichi Morita

Morita Kouichi

A nucleic acid molecule containing nucleotide sequences that encode the capsid protein, pre-membrane protein and non-structural protein of Japanese encephalitis virus, and a nucleotide sequence that encodes the envelop protein of a second flavivirus, wherein the nucleotide sequence(s) that encode(s) the pre-membrane protein and/or non-structural protein of Japanese encephalitis virus contain(s) nucleotide mutations that produce one or more amino acid mutations that attenuate the virus.

Attenuated chimeric flavivirus bearing attenuated japanese encephalitis virus gene as backbone

Attenuated chimeric flavivirus bearing attenuated Japanese encephalitis virus gene as backbone

Growing community of inventors

Kanonji, Japan

Shinichi Miyake