Toray Industries, Inc.

Fuji Electric Co., Ltd.

Nhk Spring Co., Ltd.

Katoh Electrical Machinery Company, Ltd.

Fujifilm Business Innovation Corp.

Fuji Xerox Co., Ltd.

Hitachi Global Storage Technologies Netherlands B.v.

Shinichi Kobayashi

Takanori Saito

Fumiyoshi Okano

Takayoshi Ido

Yoshitaka Minamida

Hiromu Takubo

Shinichi Ito

Katsumi Yamada

Hiroshi Miki

Akira Kojima

Yoshiharu Hibi

Yoshio Kanesawa

Yu Tsuda

Masaru Okutsu

Atsushi Miyake

Shigeki Washino

Tomio Shimizu

Kohei Genda

Shinichi Utsumi

Koji Aikawa

Sumie Takeda

Yoshinori Narita

Jun Aoki

Akira Nakahira

Taketoshi Yamashita

Kiyoshi Iida

Hisashi Goto

Kunio Shibayama

Tatsuya Hirano

Tomo Ishibashi

Tomonori Maekawa

Motohiro Fushikida

Masakazu Andou

Mitsuharu Horiuchi

Masakazu Yoshida

Atsushi Ohta

Yoshitaka Fujiwara

Toshio Ohkubo

Masanobu Takahashi

Takeki Okabayashi

Mikio Ito

Mitsuru Murakami

Yutaro Ohtomo

Keitaro Kawamura

Masahashi Nakagome

Erika Tani

Katsuhiko Sugawara

An information processing system includes: a first processor mounted on a server connected to a local network of an organization to which a user belongs, the server having a function of connecting a virtual private network; a second processor mounted on an information processing apparatus installed outside the local network; and a third processor mounted on a management apparatus installed outside the local network, the management apparatus being communicable with the server and the information processing apparatus, the third processor being configured to hold organization information comprising at least connection information corresponding to the organization in the management apparatus, the connection information being used for connection to the server, the second processor being configured to: acquire the connection information corresponding to the organization to which a user using the information processing apparatus belongs from the management apparatus; detect via the management apparatus that the organization to which the user belongs requests data communication with the information processing apparatus; and connect a virtual private network between the server and the information processing apparatus using the connection information acquired from the management apparatus, and the first processor being configured to: recognize that the virtual private network is connected between the information processing apparatus and the server; and execute data communication with the information processing apparatus via the virtual private network.

Information processing system, management apparatus, and non-transitory computer readable medium storing program

An information processing apparatus includes an extraction unit that extracts two job log entries on the basis of a relationship between a first area of a common portion and a second area of a different portion. The job log entries are associated with a single job flow, and are constituted by a certain job log entry and at least one different job log entry. The common portion and the different portion are specified between an image related to the certain job log entry and an image related to the at least one different job log entry.

Information processing apparatus and non-transitory computer readable medium capable of extracting a job flow without use of attribute information included in job entries

An optical operating input detection apparatus includes: a detection unit configured to optically detect an operating input by the operating unit on respective first and second detection layers, the first detection layer extending in parallel with a display area surface on the display panel to be spaced a predetermined distance away from the display area surface and having a surface area including the display area surface, the second detection layer being disposed between the display area surface and the first detection layer and having a surface area identical to the surface area of the first detection layer; and an operation determination unit configured to determine operating detail of the operating unit based on a detected image on the respective first and second detection layers.

Optical operating input detection apparatus, automatic vending machine, and optical operating input detection method

The present invention relates to a pharmaceutical composition for treatment and/or prevention of cancer, which comprises, as an active ingredient, an antibody or fragment thereof having an immunological reactivity with a CAPRIN-1 protein or a fragment thereof comprising 7 or more consecutive amino acids.

Pharmaceutical composition for treatment and prevention of cancers

In a vehicle seat, beads are formed to a SC panel, and the beads extend along the seat front-rear direction adjacent to joint portions at seat width direction insides of the joint portions. When repeated load in the seat up-down direction is input to a seat width direction intermediate portion of the SC panel, for example, the SC panel is displaced by the input load in the seat up-down direction, and tensile load in the seat width direction acts on the beads as a result. The beads extend or contract in the seat width direction due to the tensile load. Load input to the SC panel is thereby absorbed by the extension and contraction of the beads, and load in the seat up-down direction input to the joint portions is reduced. This enables concentration of stress at the joint portions to be suppressed.

Vehicle seat

According to the present invention, a cancer antigen protein to be specifically expressed on the surfaces of cancer cells is identified and thus the use of an antibody targeting the cancer antigen protein as an agent for treating and/or preventing a cancer is provided. Specifically, the present invention provides a pharmaceutical composition for treating and/or preventing a cancer, which comprises an antibody or a fragment thereof as an active ingredient having immunological reactivity with a partial polypeptide of CAPRIN-1, wherein CAPRIN-1 is represented by any of the even-numbered sequences of SEQ ID NOS: 2 to 30, and wherein the partial polypeptide comprises the amino acid sequence represented by SEQ ID NO: 37 or an amino acid sequence having 80% or more sequence identity with the amino acid sequence.

Pharmaceutical composition for treatment and/or prevention of cancer

This invention provides an antibody targeting a cancer antigenic protein specifically expressed on the surface of cancer cells and use thereof in a therapeutic and/or preventive agent for cancers. Specifically, this invention provides an antibody or a fragment thereof which has immunological reactivity with a partial CAPRIN-1 polypeptide consisting of the amino acid sequence represented by SEQ ID NO: 5 or an amino acid sequence having 80% or higher sequence identity to the amino acid sequence, and a pharmaceutical composition for treatment and/or prevention of cancers, comprising the antibody or fragment thereof as an active ingredient.

This invention provides an antibody targeting a cancer antigenic protein specifically expressed on the surface of cancer cells and use thereof as a therapeutic and/or preventive agent for cancer. More specifically, the present invention provides an antibody, or a fragment thereof which has immunological reactivity with a partial CAPRIN-1 polypeptide consisting of the amino acid sequence shown by SEQ ID NO: 5 or an amino acid sequence having 80% or higher sequence identity to the amino acid sequence, and a pharmaceutical composition for treatment and/or prevention of cancer comprising the same as an active ingredient.

Pharmaceutical composition for treatment and/or prophylaxis of cancer

This invention provides an antibody targeting a cancer antigenic protein specifically expressed on the surface of cancer cells and use thereof in a therapeutic and/or preventive agent for cancer. Specifically, this invention provides an antibody or a fragment thereof which has immunological reactivity with a partial CAPRIN-1 polypeptide consisting of the amino acid sequence set forth in SEQ ID NO: 5 or an amino acid sequence having 80% or higher sequence identity to the amino acid sequence, and a pharmaceutical composition for treatment and/or prevention of cancer, comprising the antibody or fragment thereof as an active ingredient.

This invention provides an antibody targeting a cancer antigenic protein specifically expressed on the surface of cancer cells and use thereof as a therapeutic and/or preventive agent for cancer. Specifically, this invention provides an antibody or a fragment thereof which has immunological reactivity with a partial CAPRIN-1 polypeptide consisting of the amino acid sequence set forth in SEQ ID NO: 5 or an amino acid sequence having 80% or higher sequence identity to the amino acid sequence, and a pharmaceutical composition for treatment and/or prevention of cancer, comprising the antibody or fragment thereof as an active ingredient.

It is intended to identify a cancer antigenic protein specifically expressed on the surface of cancer cells and to provide an antibody targeting the antigenic protein and use of the antibody as a therapeutic and/or preventive agent for cancer. The present invention provides an antibody or a fragment thereof which has immunological reactivity with a CAPRIN-1 protein, the antibody comprising a heavy chain variable region comprising amino acid sequences of SEQ ID NOs: 5, 6, and 7 and a light chain variable region comprising amino acid sequences of SEQ ID NOs: 9, 10, and 11, and a pharmaceutical composition for treatment and/or prevention of cancer, comprising this antibody or fragment as an active ingredient.

This invention provides an antibody targeting a cancer antigenic protein specifically expressed on the surface of cancer cells and use thereof as a therapeutic and/or preventive agent for cancer. More specifically, the present invention provides an antibody, or a fragment thereof which has immunological reactivity with a CAPRIN-1 protein, the antibody comprising a heavy chain variable region comprising complementarity determining regions of SEQ ID NOs: 5, 6, and 7 and a light chain variable region comprising complementarity determining regions of SEQ ID NOs: 9, 10, and 11, and a pharmaceutical composition for treatment and/or prevention of cancer, comprising the same as an active ingredient.

An object of the present invention is to prepare an antibody that targets CAPRIN-1 specifically expressed on the surface of cancer cells and is superior in antitumor activity to conventional antibodies and to provide use of the antibody as a therapeutic and/or preventive agent for cancer. The present invention provides use of an antibody targeting an identified cancer antigenic protein specifically expressed on the surface of cancer cells as a therapeutic and/or preventive agent for cancer, specifically, a pharmaceutical composition for treatment and/or prevention of cancer, comprising as an active ingredient an antibody or a fragment thereof which has immunological reactivity with a CAPRIN-1 protein, the antibody or the fragment thereof comprising a heavy chain variable region comprising amino acid sequences represented by SEQ ID NOs: 5, 6, and 7 and a light chain variable region comprising amino acid sequences represented by SEQ ID NOs: 9, 10, and 11.

Growing community of inventors

Kanagawa, Japan

Shinichi Kobayashi