Nippon Kayaku Kabushiki Kaisha

Shinichi Ishii

Hamao Umezawa

Tomio Takeuchi

Tetsuya Someno

Tetsushi Saino

Kazuo Kato

Takaaki Aoyagi

Yasushi Takahashi

A protease adsorbent wherein valyl-glycyl-argininal is bound to a water-insoluble carrier and a process for purifying TPA utilizing the same.

Protease adsorbent and process for purifying TPA utilizing the same

A biospecific adsorbent comprising pyroglutamyl-lysyl-leucyl-argininal combined with a water-insoluble support is provided. This biospecific adsorbent is useful as an adsorbent for use in affinity chromatography and can be utilized for the purification of proteases such as urokinase.

Water-insoluble biospecific absorbent containing argininal derivative

L-Argininal derivatives of the general formula: ##STR1## are disclosed. A method of manufacturing any such derivative is also disclosed. The L-argininal derivative of this invention has a strong inhibitory activity on proteases, such as serine and thiol proteases, and is expected to provide useful medicines, including those which are effective for diseases caused by abnormal elevation of protease activity.

L-Argininal derivatives and a method of manufacturing the same

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Sapporo, Japan

Shinichi Ishii