Sanwa Kagaku Kenkyusho Co., Ltd.

Shinichi Ikeda

Masayasu Kurono

Takashi Ito

Ryoichi Unno

Hiromoto Kimura

Mitsuru Oka

Noboru Kuboyama

Kiichi Sawai

Yasuaki Kondo

Toshinao Usui

Kunihiro Sumoto

Seiji Miyano

Takuji Yamaguchi

Masato Fukushima

Keiko Hasegawa

Shunshuke Ito

A glycyrrhetic acid derivative of the formula ##STR1## wherein X and Y are hydrogen atom, respectively or X is oxygen atom together with Y, A.sub.1 is methylene or carbonyl radical, A.sub.2 is hydrogen atom, cyano, carbamoyl, carboxyl radical or alkoxycarbonyl group, m and n are an integer, respectively, R.sub.1 is a radical of ##STR2## in which R.sub.2 is an alkyl, alkenyl group, phenyl radical or a substituted phenyl radical, A.sub.3 is S, O or NH, and l is an integer, a process for the preparation of the derivatives, and use of the derivative as a pharmaceutical agent.

Glycyrrhetic acid derivatives and use thereof

Novel pyrrolizidine compounds represented by the formula ##STR1## wherein R is a radical of ##STR2## R.sup.1 is hydrogen, halogen, alkyl group, alkoxy group, alkanoyl group, trifluoromethyl radical, trimethylsilyl radical or ##STR3## R.sup.2 and R.sup.3 are same or different and are hydrogen or alkyl group, respectively, R.sup.4 is hydrogen, halogen, alkyl group or alkoxy group and m is an integer of 0 to 5, salts thereof, a process for the preparation of same as well as a pharmaceutical agent comprising same.

Pyrrolizidine compounds, salts thereof, process for the preparation of

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Kusugai, Japan

Shinichi Ikeda