Honda Motor Co., Ltd.

Millennium Pharmaceuticals Limited

Kyowa Hakko Kogyo Co., Ltd.

Honda Giken Kogyo Kabushiki Kaisha

Yutaka Giken Co., Ltd.

Kyowa Hakko Kirin Co., Limited

Shinichi Ide

Eiji Tsukuda

Yuji Nomoto

Michio Ichimura

Shoji Oda

Kenji Matsuno

Makoto Yazaki

Yoshiyuki Matsuda

Mitsuaki Kubota

Robert M Scarborough

Anjali Pandey

Junko Sasaki

Masahiro Akiyama

Shigeki Fujiwara

Junko Irie

Tetsu Wada

Hiroshi Yamamoto

Hiroshi Takahashi

Tetsuro Ikeno

Koji Kasai

Shoji Hasei

Toyoshi Yasuda

Shigekazu Sakata

Yoshimi Watanabe

Tokuji Yoshimoto

Tsuyoshi Yoshigasaki

Shoichi Rinzaki

Kentaro Furuya

Teruhiko Otsuki

Shigeo Terada

Takahiro Miyata

An outboard motor has an engine, an engine cover forming an engine compartment for holding the engine therein, a ventilation system with an outer outlet ventilation space through which air in the engine compartment flows to the outside of the engine compartment, and a generator. The ventilation system includes a case disposed in the engine compartment and forming an air discharge passage leading to the outer outlet ventilation space. A fan is placed in the air discharge passage to deliver air by pressure from the engine compartment to the outer outlet ventilation space. The air discharge passage has an inlet ventilation passage formed in an upper space in the engine compartment and opening upward. The engine compartment holding the engine therein can be efficiently ventilated, and ventilation air can effectively cool the engine and can effectively suppress temperature rise in the engine compartment.

Outboard motor

An outboard motor has an internal combustion engine, an engine cover forming an engine compartment for holding the internal combustion engine therein, and a top cover covering the engine cover from above and provided with a carrying grip. An intermediate member is placed in a space between the engine cover and the top cover. First connecting parts for connecting the engine cover and the intermediate member are arranged in a space between the engine cover and the intermediate member, and second connecting parts for connecting the top cover and the intermediate cover are arranged in a space between the top cover and the intermediate cover. The connecting parts arranged in the spaces between the engine cover and the top cover ensure rigid connection, the degree of freedom of arranging the connecting parts is increased, and the engine cover can be manufactured at low cost.

A vertical power unit includes: an engine having a vertically arranged crankshaft; a vertically arranged output shaft provided below the crankshaft; and a torque converter providing a connection between the crankshaft and the output shaft. The torque converter is arranged so as to be offset from the crankshaft toward a cylinder block of the engine. A transmission device is provided between the crankshaft and the torque converter. The output shaft is arranged coaxially with the torque converter. Thus, the center of gravity of the vertical power unit is positioned as close as possible to the central portion of the engine, thereby minimizing bias of the center of gravity due to the weight of the torque converter and the output shaft to facilitate the handling of the vertical power unit.

Vertical power unit and outboard engine system

The present invention relates to nitrogen-containing heterocyclic compounds and pharmaceutically acceptable salts thereof which have inhibitory activity on the phosphorylation of kinases, which inhibits the activity of such kinases. The invention is also related to a method of inhibiting kinases and treating disease states in a mammal by inhibiting the phosphorylation of kinases. In a particular aspect the present invention provides nitrogen-containing heterocyclic compounds and pharmaceutically acceptable salts thereof which inhibit phosphorylation of a PDGF receptor to hinder abnormal cell growth and cell wandering, and a method for preventing or treating cell-proliferative diseases such as arteriosclerosis, vascular reobstruction, cancer and glomerulosclerosis.

Quinazoline derivatives as kinase inhibitors

Nitrogenous heterocyclic compounds

An outboard engine system includes: a casing coupled to a swivel case via a swivel shaft; an engine mounted in an upper part of the casing such that a crankshaft of the engine is vertically arranged and a cylinder block of the engine faces in a direction opposite to the swivel shaft; a torque converter; a vertically arranged output shaft connected to the crankshaft through the torque converter; a horizontally arranged propeller shaft provided below the output shaft; and a forward-reverse shifting gear mechanism for providing a connection between the output shaft and the propeller shaft; the torque converter, the output shaft, the propeller shaft and the forward-reverse shifting gear mechanism being disposed in the casing. The crankshaft and the torque converter which is coaxially connected to a lower end of the crankshaft are disposed above the swivel shaft; and the torque converter and the output shaft which is disposed behind the swivel shaft are connected to each other via a transmission device. Thus, it is possible to minimize a bending moment which the swivel shaft receives due to the weight of the engine and the torque converter, in the case where the torque converter is used in the outboard engine system, thereby providing an excellent steering performance.

Outboard engine system

An outboard motor S has a first drive shaftdirectly interlocked with an engine E, a second drive shaft, an intermediate gear mechanisminterlocking the first drive shaftand the second drive shaft, an output gear mechanismdriven by power transmitted thereto through the second drive shaft, a propeller shaftdriven for rotation by power transmitted thereto through the output gear mechanism, and a gear caseholding the output gear mechanism. The second drive shaftextends downward beyond a vertical position corresponding to the lower end of the first drive shaft. The gear caseis provided with water intakesthrough which a water pumpsucks water in a space between the first drive shaftand the output gear mechanismwith respect to a vertical direction on the front side of the second drive shaft. The space for the water intakescan be easily secured because the second drive shaftis disposed on the rear side of the first drive shaft

Marine propulsion machine provided with drive shaft

An outboard motor has an internal combustion engine installed in an engine compartment defined by an engine cover. The engine's intake air inlet is formed by an air intake duct, which communicates with an air intake space outside the engine compartment. The engine cover includes an upper cover with a receiving ring fitted on the air intake duct. The receiving ring and the intake duct form an overlapping part in which the ring and the duct overlap each other in the direction of flow of combustion air. The overlapping part has a sealing member therein which forms a seal between the air intake space and the interior space of the engine compartment. The sealing structure does not require high dimensional precision to form a required sealing property between the engine cover and the air inlet of the engine intake system. The sealing structure minimizes any influence of engine vibrations.

Internal combustion engine installed in engine compartment

In an outboard motor S, a first drive shaftand a second drive shaftare interlocked by an intermediate gear mechanismincluding a drive gearmounted on the first drive shaftand a driven gearmounted on the second drive shaft. The second drive shaftis supported in an upper bearingand a lower bearingdisposed on the upper and the lower side of the driven gear. The upper bearingsupports an upper end partof the second drive shaftextending upward from the driven gearand the upper bearingis at a vertical position coinciding with that of the drive gear. The lower bearingis placed at a position on a lower end partof the second drive shaft. The lower end partextends between the driven gearand an input gearincluded in the output gear mechanism. The first drive shaftdrives an oil pumpfor supplying moving parts requiring lubrication and placed in a gear caseholding the output gear mechanisminterlocked with the second drive shaft. The second drive shaftis short and light, the outboard motor can be manufactured at a low manufacturing cost and the oil pumpis small.

Marine propulsion machine having drive shaft

A vertical power unit includes an input shaft and an output shaft which have axes in the vertical direction and are vertically arranged to each other; and a torque converter between the input shaft and the output shaft. The output shaft includes an upper output shaft connected to a turbine runner and a lower output shaft connected to the upper output shaft. An oil tank and an oil pump are provided outside the torque converter. The upper output shaft is provided with a vertical hole which communicates at an upper end with a circulation circuit of the torque converter so as to introduce the oil discharged by the oil pump into the circulation circuit, and a bottom wall which closes a lower end of the vertical hole. Thus, an working oil is constantly supplied to the circulation circuit of the torque converter through the interior of the output shaft, thereby cooling the working oil in the circulation circuit, and improves maintainability of loading devices driven by the output shaft.

An internal combustion engine installed in an engine compartmentcovered with an engine cover C is provided with an intake air passage P. The intake air passage P extends continuously from an intake air inlet Pi to intake air outlets Pe in the engine compartmentand has a first down passage, a reversing passage, an up passageand a second down passagearranged in the order in the flowing direction of combustion air. The combustion air taken through the intake air inlet Pi into the intake air passage P flows down through the first down passage, the reversing passagereverses the flowing direction of the combustion air that has flowed down through the first down passagesuch that the combustion air flows up, flows up through the up passageto a position at a level higher than that of an uppermost intake air outlet Pe. Then, the combustion air flows down through the second down passageand flows through the intake air outlets Pe into combustion chambers. Thus, an effect on preventing the flow of water into the combustion chamberof the engine is improved.

Internal combustion engine and outboard motor provided with the same

An outboard motor S has: a first drive shaftinterlocked with an internal combustion engine, a second drive shaftinterlocked with the first drive gear, an output gear mechanismdriven by the second drive shaft, a propeller shaft, and a gear caseholding the output gear mechanismand the propeller shaftand having a normally submerged gearing holding portion. The second drive shaftis disposed rearward of the first drive shaftwith respect to a longitudinal direction. The gearing holding portionhas a tapered partextending forward from a position corresponding to the second drive shaftand having a front end. The tapered partis tapered toward the front. The disposition of the second drive shaftrearward of the first drive shaftenables forming the gear casein a small size and reduces underwater resistance to the gear case

An outboard engine system includes: an engine; a casing to which the engine is removably mounted at an upper portion; a torque converter; a vertically arranged output shaft connected to a crankshaft via the torque converter; a horizontally arranged propeller shaft provided below the output shaft; and a forward-reverse shifting gear mechanism for providing a connection between the output shaft and the propeller shaft. The casing includes: casing main sections for housing the output shaft, the propeller shaft, and the forward-reverse shifting gear mechanism; and distance members removably jointed to the upper end of the casing main sections so as to house the torque converter. Both the casing main sections and the distance members are configured to be able to removably mount the engine. Thus, the casing having the main sections can be used in both an outboard engine system with a torque converter and an outboard engine system without a torque converter.

A vertical fluid power transmission includes: a vertical crankshaft of an engine; a vertical output shaft; and a vertical torque converter disposed between the crankshaft and the output shaft. An oil supply passage is connected to one end of the circulation circuit of the vertical torque converter, and guides a stored oil that is drawn up from an oil tank and discharged by an oil pump. An oil return passage is connected to the other one end of the circulation circuit, and leads to the oil tank. A normally-closed pressure response valve is provided in the oil return passage. The pressure response valve is opened by an upstream pressure. Thus, the oil tank for storing a working oil of the torque converter is separated from the torque converter, thereby downsizing the torque converter, and the working oil is circulated between the oil tank and the circulation circuit of the torque converter, thereby promoting cooling of the working oil.

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Wako, Japan

Shinichi Ide