Ajinomoto Co., Ltd.

Shinichi Fujita

Seiji Niwa

Tomoko Takeda

Satoshi Iwayama

Hajime Koganei

Akira Takahara

Yukitsugu Ono

Seiji Ohno

Kayo Otani

Youji Yamada

Tamotsu Suzuki

Tatsuya Okuzumi

Tadakiyo Nakagawa

Yoichiro Shima

Takashi Yamamoto

Masahiro Murata

Toshihiko Yoshimura

Tetsuo Yano

Masako Hagihara

Akiko Okajima

Keiko Moki

Kaoru Takenaka

Masanao Yoshida

Hiroshi Yamamoto

Hideki Matsumoto

Naoyuki Fukuchi

Munetaka Tokumasu

Shingo Makino

Sayaka Asari

Hisayuki Uneyama

Masataka Shoji

Itsuya Tanabe

Masaki Hashimoto

Yoriko Yamamoto

Tatsuro Ajinomoto Co Inc Tanaka

Hisayuki Ajinomoto Co Inc Uneyama

The invention relates to a compound represented by the following general formula (1) or its analogue, which selectively inhibit N-type calcium channels or its analogue, and to a method for treating pain etc. comprising the compound represented by the following general formula (1) or its analogue to a patient in need of such treatment: wherein, A represents CH&#x2550;CH, etc., a, b, c and d represents CH etc., R1, R2, R3, R4, R5 and R6 represents H etc., V&#x2014;W represents C&#x2550;C, etc., n represents 0 to 3, Y1 represents O etc., B represents &#x2014;(CH2)vCHR21 wherein v is 0 to 3, R21 represents H, a lower alkyl group or the like, etc., G represents &#x2014;CO&#x2014;, a covalent bond, etc., m is 0 to 6, R7 and R8 represents H, a lower alkyl group, &#x2014;COR18a, &#x2014;COOR20 wherein R18a and R20 each represents a lower alkyl group or the like, etc.

Diarylalkene derivatives and novel diarylalkane derivatives

Amide derivatives represented by the formula (I): wherein:

Amide derivative

The present invention relates to an ether derivative represented by the formula (I), a pharmaceutically acceptable salt thereof, a hydrate thereof or a solvate thereof wherein each symbol is as defined in the description, and an ether derivative represented by the formula (III), a pharmaceutically acceptable salt thereof, a hydrate thereof or a solvate thereof wherein each symbol is as defined in the description; a pharmaceutical composition containing the ether derivative; and a package containing the pharmaceutical composition and a description of use thereof. A pharmaceutical composition of the present invention, which contains this compound of the present invention has a superior anti-inflammatory and analgesic activity and is useful as various pharmaceutical agents such as an anti-inflammatory agent, an analgesic, a therapeutic agent for inflammatory bowel disease, a therapeutic agent for pollakiuria and/or incontinentia, a therapeutic agent for asthma and the like.

Ether derivative

The present invention relates to a pharmaceutical composition useful for preventing/treating pain, which comprises combination of gabapentin or pregabalin, or pharmaceutically acceptable salts thereof and N-type calcium channel antagonists or pharmaceutically acceptable salts thereof such as a compound having the following structure. 

Pharmaceutical composition containing gabapentin or pregabalin and N-type calcium channel antagonist

The present invention provides a piperidine derivative represented by the following formula or analogs thereto, which are used for agents for treating or preventing various diseases related to 5-HT7. 

Piperidine derivative

Achiral pyrimidine derivatives and pyridine derivatives of the following formulae or analogs thereof have selective N-type calcium channel antagonistic activity and showed analgesic action when they were taken orally. They are useful as therapeutic agents for pains and various diseases associated with the N-type calcium channels. 

Pyridine compounds useful as N-type calcium channel antagonists

Achiral pyrimidine derivatives and pyridine derivatives of the following formulae or analogs thereof have selective N-type calcium channel antagonistic activity and showed analgesic action when they were taken orally. They are useful as therapeutic agents for pains and various diseases associated with the N-type calcium channels 

Pyrimidine compounds useful as N-type calcium channel antagonists

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Kawasaki, Japan

Shinichi Fujita