Taiho Pharmaceutical Company Limited

Shinichi Aoki

Hiroyoshi Yamanaka

Takahiro Asai

Masanori Asai

Masato Nanri

Shigeo Okajima

Kazuhisa Minamiguchi

Fukumitsu Sakakibara

Suguru Dohi

Yoshikazu Iwasawa

Yoshihiro Urade

Makoto Kitade

Keiko Yamane

Kazuharu Noguchi

A method for inhibiting androgen activity, including administering an effective amount of a tetrahydropyridopyrimidine compound of formula (I) or a pharmaceutically acceptable salt thereof to a subject in need thereof, and a method for treating tumor, including administering an effective amount of a tetrahydropyridopyrimidine compound of formula (I) or a pharmaceutically acceptable salt thereof to a subject in need thereof 

Tetrahydropyridopyrimidine compound or salt thereof

An acetic acid ester compound represented by the following formula (I) or a salt thereof, wherein R represents optionally substituted deuterated lower alkyl, is disclosed.

Acetic acid ester compound or salt thereof

A benzilic acid ester compound represented by the following formula (I) or a salt thereof, 

Fluorinated benzilic acid ester compound and salt thereof

A tetrahydropyridopyrimidine compound represented by formula (I) or a pharmaceutically acceptable salt thereof; and a pharmaceutical composition including the tetrahydropyridopyrimidine compound or a pharmaceutically acceptable salt thereof and a pharmaceutically acceptable carrier: 

The present invention provides a piperidine compound represented by Formula (I) (wherein X, X, X, A, B and N are as defined in the Description); or a salt thereof.

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Tsukuba, Japan

Shinichi Aoki