Shino-test Corporation

Renesas Electronics Corporation

Kumamoto University

Kagoshima University

Shingo Yamada

Ikuro Maruyama

Yukio Ando

Keiichi Inoue

Megumi Kitajime

Hajime Yoshimura

Ikunosuke Sakurabayashi

The invention addresses providing a semiconductor device that enables to reduce noise simultaneous with switching. A driver IC which is a semiconductor device includes a drive circuit which drives a control terminal of a PMOS drive stage which is a switching element, a noise detection circuit which detects noise in an output signal when switching (turning) the PMOS drive stage on or off, and a control circuit which control driving by the drive circuit based on the detected noise.

Semiconductor device and control method thereof

Previously, it was difficult to obtain high-affinity antibodies that specifically bind to HMGB-1 but not to HMGB-2. Under this circumstance, the present inventors successfully obtained antibodies that are more reactive to HMGB-1 than to HMGB-2 by using specific peptides as an antigen. The present inventors also demonstrated that the antibodies had a HMGB-1-neutralizing activity. The present inventors administered the antibodies to amyloidosis model animals, and as a result, successfully demonstrated that the antibodies produced a significant therapeutic effect.

Method of treating amykloidosis comprising administering an anti-HMGB-1 antibody

Peptides including amino acid sequences selected from lipoprotein (a)

Growing community of inventors

Tokyo, Japan

Shingo Yamada