Meiji Seika Kaisha, Ltd.

Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai

Shingo Uchida

Hiroshi Watanabe

Takashi Shomura

Michio Kojima

Takashi Hisamatsu

Tomio Takeuchi

Takashi Tsuruoka

Shigeharu Inouye

Takaaki Aoyagi

Taro Niida

Katsuyoshi Iwamatsu

Shigeharu Inoue

Shoji Omoto

Yasuaki Ogawa

Kazunori Ohba

Takao Iwaguchi

Mariko Shimamura

Actinonin or a salt thereof is active as an inhibitor of angiogenesis in a mammal and is useful as a therapeutic agent for inhibiting angiogenesis in a mammal having diabetic retinopathy or inflammatory response accompanied by angiogenesis.

Pharmaceutical composition and method for angiogenesis inhibition

An antibiotic SF-1942 substance produced by cultivating an SF-1942 substance producing strain of the genus Streptomyces in a nutrient medium under aerobic conditions to produce and accumulate the SF-1942 substance in the nutrient medium and isolating the SF-1942 substance from the fermentation broth followed by purification and a process for the production of the antibiotic SF-1942 substance. The SF-1942 substance is effective as an antimicrobial agent and an antitumor agent against Sarcoma 180 tumor cells in mice.

Antibiotic SF-1942 substance and process for production of the same

New antibiotics SF-1130-x.sub.1 substance and SF-1130-x.sub.2 substance are produced by cultivating a microorganism Streptomyces myxogenes SF-1130 now deposited under FERM-P. 676 and ATCC. 31305 in a liquid culture medium under aerobic conditions, and these antibiotics may be isolated from the fermentation broth and are useful as an activator for enhancing the host defense system in living animals. The activity of these antibiotics may be improved when used in combination with one or more of maltose, maltotriose, maltotetraose, maltopentaose, maltohexaose and maltoheptaose.

Antibiotics SF-1130-x.sub.1 and -x.sub.2 substances and production and

Growing community of inventors

Yokohama, Japan

Shingo Uchida