Nissan Chemical Industries Limited

Shingo Owada

Kazufumi Yanagihara

Norihisa Ishiwata

Yutaka Hirokawa

Katsuaki Miyaji

Shunsuke Iwamoto

Yukihiro Shigeta

Takanori Nakamura

Hirofumi Ota

Satoshi Nakano

Masato Horikawa

Koji Toyama

Shunuske Iwamoto

Katsuaki Myaji

A compound represented by the formula (1): wherein A, B, R, L, R, L, L, Y, L, Rand X are the same as defined in the description, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof. 

3-ethylidenehydrazino substituted heterocyclic compounds as thrombopoietin receptor activators

A compound represented by the formula (1): wherein A is a nitrogen atom or CR, B is an oxygen atom, a sulfur atom or NR(provided that when A is a nitrogen atom, B is not NH), Ris a Caryl group, Lis a bond, CRR, an oxygen atom, a sulfur atom or NR, X is OR, SRor NRNR, Ris a hydrogen atom, a formyl group, a Calkyl group or the like, Lis a bond or the like, Lis a bond, CRR, an oxygen atom, a sulfur atom or NR, Lis a bond, CRR, an oxygen atom, a sulfur atom or NR, Y is an oxygen atom, a sulfur atom or NR, and Ris a Caryl group, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.

Heterocyclic compounds and thrombopoietin receptor activators

The present invention provides compounds useful for prevention, treatment or alleviation of diseases against which activation of the thrombopoietin receptor is effective. A compound represented by the formula (1): wherein A, B, R, L, R, L, L, Y, L, Rand X are the same as defined in the description, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.

Amide compound and thrombopoietin receptor activator

A compound represented by the formula (I) (wherein R, R, Rand Rare as defined in the description), a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof. 

Thiophene compounds and thrombopoietin receptor activators

A compound represented by the formula (1): wherein A is a nitrogen atom or CR, B is an oxygen atom, a sulfur atom or NR(provided that when A is a nitrogen atom, B is not NH), Ris a Caryl group, Lis a bond, CRR, an oxygen atom, a sulfur atom or NR, X is OR, SRor NRNR, Ris a hydrogen atom, a formyl group, a Calkyl group or the like, Lis a bond or the like, Lis a bond, CRR, an oxygen atom, a sulfur atom or NR, Lis a bond, CRR, an oxygen atom, a sulfur atom or NR, Y is an oxygen atom, a sulfur atom or NR, and Ris a Caryl group, a tautomer, prodrug or is pharmaceutically acceptable salt of the compound or a solvate thereof.

A compound represented by the formula (1): wherein A is a nitrogen atom or CR, B is an oxygen atom, a sulfur atom or NR(provided that when A is a nitrogen atom, B is not NH), Ris a Caryl group, Lis a bond, CRR, an oxygen atom, a sulfur atom or NR, X is ORSRor NRNR, Ris a hydrogen atom, a formyl group, a Calkyl group or the like, Lis a bond or the like, Lis a bond, CRR, an oxygen atom, a sulfur atom or NR, Lis a bond, CRR, an oxygen atom, a sulfur atom or NR, Y is an oxygen atom, a sulfur atom or NR, and Ris a Caryl group, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.

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Funabashi, Japan

Shingo Owada