Sumitomo Dainippon Pharma Co., Ltd.

The Kitasato Institute

Sumitomo Pharma Co., Ltd.

Shingo Mizushima

Toshio Kanai

Toshiaki Sunazuka

Yohei Ikuma

Sachiko Koike

Kohei Iwamoto

Masafumi Komiya

Keiji Adachi

Shunichiro Uesugi

Hitoshi Suda

Yoshihiko Noguchi

Yuki Mizukami

Kuniko Urashima

Takayuki Fukaya

Yoko Takahashi

Shoukou Lee

Provided is a novel compound that has an excellent &#x3b2;-lactamase inhibitory effect. More specifically, provided is a compound represented by formula (1a), (1b) or (11) having an excellent &#x3b2;-lactamase inhibitory effect or a pharmaceutically acceptable salt thereof. By using this compound either in combination with a &#x3b2;-lactam drug or alone, a useful preventive or therapeutic agent for bacterial infections is provided. Also provided are useful preventive or therapeutic agents for treating various diseases with the combined use of the aforesaid compound and &#x3b2;-lactam drugs.

Oxo-substituted compound

The present invention relates to a process to prepare a benzimidazole derivative useful as a medicament, an intermediate for preparing the medicament, and a process to prepare the intermediate.

Method for producing benzimidazole derivative

The present invention provides a medicament for treating a disease involving Nav 1.7 such as neuropathic pain, nociceptive pain, inflammatory pain, small-fiber neuropathy, erythromelalgia, paroxysmal extreme pain disorder, dysuria, and multiple sclerosis, which comprises a compound of formula (I): or a pharmaceutically acceptable salt thereof, wherein R, R, Rand Rare hydrogen, halogen, cyano, Calkyl, Calkoxy, or the like, provided that at least one of R, R, Rand Ris Caryl, Caryloxy, or the like, Rand Rare hydrogen, Calkyl, Ccycloalkyl, or the like, Ris hydrogen, Calkyl, Ccycloalkyl, or the like, m is 1, 2 or 3, L is CRR, and Rand Rare hydrogen, hydroxyl, Calkyl, Calkoxy, or the like.

Benzimidazole compound and medical use thereof

Benzimidazole compounds and medical uses thereof

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Osaka, Japan

Shingo Mizushima